Evidence map›Paper›PMID 32894319›Full record

ReviewDiabetologia2020

CNS control of the endocrine pancreas.

Chelsea L Faber, Jennifer D Deem, Carlos A Campos, Gerald J Taborsky, Gregory J Morton

Abstract readReview
In one paragraph

Review in Diabetologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Postprandial Glucagon Action in the Human Brain.Diabetes, obesity & metabolism · 2026
    Article
  6. Review
  7. PVNJournal of neuroinflammation · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Microglia mediate the early-life programming of adult glucose control.bioRxiv : the preprint server for biology · 2024
    Article
  20. Neuroimmune regulation in the pancreas.Fundamental research · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chelsea L FaberUW Medicine Diabetes Institute, Department of Medicine, University of Washington, 750 Republican St, Box 358062, Seattle, WA, 98109, USA.ORCID 0000-0002-4812-8164
Jennifer D DeemUW Medicine Diabetes Institute, Department of Medicine, University of Washington, 750 Republican St, Box 358062, Seattle, WA, 98109, USA.ORCID 0000-0002-8865-5145
Carlos A CamposUW Medicine Diabetes Institute, Department of Medicine, University of Washington, 750 Republican St, Box 358062, Seattle, WA, 98109, USA.
Gerald J TaborskyDepartment of Medicine, University of Washington, Seattle, WA, USA.
Gregory J MortonUW Medicine Diabetes Institute, Department of Medicine, University of Washington, 750 Republican St, Box 358062, Seattle, WA, 98109, USA. gjmorton@uw.edu.ORCID 0000-0002-8106-8386

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Diabetes, Obesity and Metabolism Training ProgramT32DK007247 · NIDDK · UNIVERSITY OF WASHINGTON · PI GREGORY J MORTON, KRISTINA Marie UTZSCHNEIDER · 1986 to 2026
$10.0M
Nutrition, Obesity and Atherosclerosis Training ProgramT32HL007028 · NHLBI · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1985 to 2026
$6.4M
Neuroendocrine Control of Glucose MetabolismR01DK089056 · NIDDK · UNIVERSITY OF WASHINGTON · PI MORTON, GREGORY J · 2011 to 2024
$5.6M
Molecular Medicine Training ProgramT32GM095421 · NIGMS · UNIVERSITY OF WASHINGTON · PI HAWN, THOMAS R, LILES, W. CONRAD · 2011 to 2020
$1.6M
Dissecting Viscerosensory Pathways Controlling Feeding BehaviorK01DK124245 · NIDDK · UNIVERSITY OF WASHINGTON · PI CAMPOS, CARLOS A · 2020 to 2024
$749k
Neurocircuits linking thermoregulation and feedingK01DK126793 · NIDDK · UNIVERSITY OF WASHINGTON · PI DEEM, JENNIFER DEZET · 2021 to 2022
$257k
Identification of a neural circuit controlling blood glucoseF31DK113673 · NIDDK · UNIVERSITY OF WASHINGTON · PI FABER, CHELSEA LEIGH · 2017 to 2019
$116k
American Diabetes Association ADA 1-19-PDF-103NHLBI NIH HHS T32 HL007028NIDDK NIH HHS F31 DK113673NIDDK NIH HHS K01 DK124245NIDDK NIH HHS K01 DK126793NIDDK NIH HHS P30 DK017047NIDDK NIH HHS R01 DK089056NIDDK NIH HHS T32 DK007247NIGMS NIH HHS T32 GM095421
6 · The paper itself

Abstract

Increasing evidence suggests that, although pancreatic islets can function autonomously to detect and respond to changes in the circulating glucose level, the brain cooperates with the islet to maintain glycaemic control. Here, we review the role of the central and autonomic nervous systems in the control of the endocrine pancreas, including mechanisms whereby the brain senses circulating blood glucose levels. We also examine whether dysfunction in these systems might contribute to complications of type 1 diabetes and the pathogenesis of type 2 diabetes. Graphical abstract.

Indexed as

AnimalsAutonomic Nervous SystemBlood GlucoseCentral Nervous SystemDiabetes Mellitus, Type 2GlucagonHumansInsulinInsulin SecretionIslets of LangerhansSensory Receptor CellsBlood GlucoseGlucagonInsulinAutonomic nervous systemBrainDiabetesGlucagonGlucoseInsulinIsletPancreasReview

Identifiers

PMID32894319
PMCPMC7983553

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.