Evidence map›Paper›PMID 32894140›Full record

Trial reportJournal of the International Society of Sports Nutrition2020

Supplement with whey protein hydrolysate in contrast to carbohydrate supports mitochondrial adaptations in trained runners.

Mette Hansen, Mikkel Oxfeldt, Anne E Larsen, Lise S Thomsen, Torben Rokkedal-Lausch, Britt Christensen, Nikolaj Rittig, Frank V De Paoli, Jens Bangsbo, Niels Ørtenblad and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03561337 (Effect of Whey Protein Hydrolysate on Adaptions to Endurance Training in Well-trained Runners), which is not on this map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03561337 nacompletednot on this map

Effect of Whey Protein Hydrolysate on Adaptions to Endurance Training in Well-trained Runners

TypeinterventionalSponsorUniversity of AarhusRan2013 to 2014Enrolled24ConditionsPerformance, Nutrition, ProteinArmsPROTEIN-CARBOHYDRATE, CARBOHDYRATE
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mette HansenSection for Sport Sciences, Department of Public Health, Aarhus University, Dalgas Avenue 4, 8000, Aarhus C, Denmark. mhan@ph.au.dk.
Mikkel OxfeldtSection for Sport Sciences, Department of Public Health, Aarhus University, Dalgas Avenue 4, 8000, Aarhus C, Denmark.ORCID http://orcid.org/0000-0003-0058-6964
Anne E LarsenSection for Sport Sciences, Department of Public Health, Aarhus University, Dalgas Avenue 4, 8000, Aarhus C, Denmark.
Lise S ThomsenDepartment of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Torben Rokkedal-LauschDepartment of Health Science and Technology, Aalborg University, Aalborg, Denmark.
Britt ChristensenDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Nikolaj RittigDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Frank V De PaoliDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Jens BangsboDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Niels ØrtenbladDepartment of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Klavs MadsenSection for Sport Sciences, Department of Public Health, Aarhus University, Dalgas Avenue 4, 8000, Aarhus C, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProtein supplementation has been suggested to augment endurance training adaptations by increasing mixed muscle and myofibrillar protein synthesis and lean body mass. However, a potential beneficial effect on mitochondrial adaptations is yet to be clarified. The aim of the present study was to investigate the effect of consuming whey protein hydrolysate before and whey protein hydrolysate plus carbohydrate (PRO-CHO) after each exercise session during a six-week training period compared to similarly timed intake of isocaloric CHO supplements on biomarkers of mitochondrial biogenesis, VO

methodsTwenty-four trained runners (VO

resultsFollowing six weeks of endurance training Cytochrome C (Cyt C) protein content was significantly higher in the PRO-CHO group compared to the CHO group (p < 0.05), with several other mitochondrial proteins (Succinate dehydrogenase (SDHA), Cytochrome C oxidase (COX-IV), Voltage-dependent anion channel (VDAC), Heat shock protein 60 (HSP60), and Prohibitin (PHB1)) following a similar, but non-significant pattern (p = 0.07-0.14). β-hydroxyacyl-CoA dehydrogenase (HAD) activity was significantly lower after training in the CHO group (p < 0.01), but not in the PRO-CHO group (p = 0.24). VO

conclusionIntake of whey PRO hydrolysate before and whey PRO hydrolysate plus CHO after each exercise session during a six-week endurance training period may augment training effects on specific mitochondrial proteins compared to intake of iso-caloric CHO but does not alter VO

trial registrationclinicaltrials.gov , NCT03561337 . Registered 6 June 2018 - Retrospectively registered.

Indexed as

Adaptation, PhysiologicalDietary SupplementsAdolescentAdultBeveragesBody CompositionDietary CarbohydratesFemaleHeart RateHumansMaleMiddle AgedMitochondrial ProteinsMitochondria, MuscleOrganelle BiogenesisOxygen ConsumptionDietary CarbohydratesMitochondrial ProteinsPHB protein, humanProhibitinsProtein HydrolysatesEndurance sportEnzyme activityMitochondriaPerformanceProtein hydrolysateSkeletal muscleSports nutrition

Identifiers

PMID32894140
PMCPMC7487963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.