Evidence map›Paper›PMID 32894018›Full record

ArticleJournal of medicinal chemistry2020

Synthesis and Evaluation of 4-Hydroxycoumarin Imines as Inhibitors of Class II Myosins.

Jhonnathan Brawley, Emily Etter, Dante Heredia, Amarawan Intasiri, Kyle Nennecker, Joshua Smith, Brandon M Welcome, Richard K Brizendine, Thomas W Gould, Thomas W Bell and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Postsynaptic Calcium Extrusion at the Mouse Neuromuscular Junction Alkalinizes the Synaptic Cleft.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Jhonnathan BrawleyDepartment of Chemistry, University of Nevada, Reno, Nevada 89557-0216, United States.
Emily EtterDepartment of Pharmacology, University of Nevada, Reno School of Medicine, Reno, Nevada 89557-0318, United States.
Dante HerediaDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, Nevada 89557-0352, United States.
Amarawan IntasiriDepartment of Chemistry, University of Nevada, Reno, Nevada 89557-0216, United States.
Kyle NenneckerDepartment of Pharmacology, University of Nevada, Reno School of Medicine, Reno, Nevada 89557-0318, United States.
Joshua SmithDepartment of Pharmacology, University of Nevada, Reno School of Medicine, Reno, Nevada 89557-0318, United States.
Brandon M WelcomeDepartment of Pharmacology, University of Nevada, Reno School of Medicine, Reno, Nevada 89557-0318, United States.
Richard K BrizendineDepartment of Pharmacology, University of Nevada, Reno School of Medicine, Reno, Nevada 89557-0318, United States.
Thomas W GouldDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, Nevada 89557-0352, United States.
Thomas W BellDepartment of Chemistry, University of Nevada, Reno, Nevada 89557-0216, United States.ORCID 0000-0003-4986-9180
Christine CremoDepartment of Pharmacology, University of Nevada, Reno School of Medicine, Reno, Nevada 89557-0318, United States.
University of Nevada, Reno · US

Funding

Mechanochemistry of Myosin II FilamentsR01AR071405 · NIAMS · UNIVERSITY OF NEVADA RENO · PI BAKER, JONATHAN E., CREMO, CHRISTINE R · 2017 to 2021
$2.1M
Probing the terminal / perisynaptic Schwann cell transcriptome in early stages of motor neuron disease using a RiboTag approach.R21NS107922 · NINDS · UNIVERSITY OF NEVADA RENO · PI GOULD, THOMAS · 2018 to 2019
$392k
NIAMS NIH HHS R01 AR071405NINDS NIH HHS R21 NS107922
6 · The paper itself

Abstract

Inhibitors of muscle myosin ATPases are needed to treat conditions that could be improved by promoting muscle relaxation. The lead compound for this study ((3-(

Indexed as

4-HydroxycoumarinsAdenosine TriphosphatasesIminesMolecular Docking SimulationMuscle, SkeletalMyosinsStructure-Activity Relationship4-HydroxycoumarinsAdenosine TriphosphatasesIminesMyosins

Identifiers

PMID32894018
PMCPMC8244571
OpenAlexW3084204448

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.