ArticleGigaScience2020
Generation of a chromosome-scale genome assembly of the insect-repellent terpenoid-producing Lamiaceae species, Callicarpa americana.
Article in GigaScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 49 citations in OpenAlex.
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- Comparative transcriptomic and co-expression analyses enable the discovery of key enzymes responsible for oleuropein biosynthesis in olive (Olea europaea).Plant communications · 2026Article
- Diterpenoids in medicinal plants: structure, distribution, biological activities, biosynthesis, and bioengineering prospects.Frontiers in plant science · 2026Review
- Transcriptional and functional characterization of terpene synthase genes of the aromatic plant Plectranthus hadiensis.PloS one · 2026Article
- The Complete Mitochondrial Genome ofBiology · 2025Article
- A Review and Survey of Local Eastern Kentucky Medicinal Plants and Their Pharmacological Benefits.Plants (Basel, Switzerland) · 2025Review
- A high-quality genome assembly of the tetraploid Teucrium chamaedrys unveils a recent whole-genome duplication and a large biosynthetic gene cluster for diterpenoid metabolism.Plant communications · 2025Article
- Three cytochrome P450 enzymes consecutively catalyze the biosynthesis of furanoclerodane precursors in Salvia species.Plant communications · 2025Article
- Chromosome-level genome assembly of an important ethnic medicinal plant Callicarpa nudiflora.Scientific data · 2025Article
- CYP76BK1 orthologs catalyze furan and lactone ring formation in clerodane diterpenoids across the mint family.The Plant journal : for cell and molecular biology · 2024Article
- Pseudomolecule-scale genome assemblies of Drepanocaryum sewerzowii and Marmoritis complanata.G3 (Bethesda, Md.) · 2024Article
- A chromosome level reference genome of Diviner's sage (Salvia divinorum) provides insight into salvinorin A biosynthesis.BMC plant biology · 2024Article
- Chromosome-scale Salvia hispanica L. (Chia) genome assembly reveals rampant Salvia interspecies introgression.The plant genome · 2024Article
- CYP76BK1 orthologs catalyze furan and lactone ring formation in clerodane diterpenoids across the mint family.bioRxiv : the preprint server for biology · 2024Article
- Allopolyploid origin and diversification of the Hawaiian endemic mints.Nature communications · 2024Article
- Chromosome-level genome assembly provides insights into the genome evolution and functional importance of the phenylpropanoid-flavonoid pathway in Thymus mongolicus.BMC genomics · 2024Article
- High quality genomes produced from single MinION flow cells clarify polyploid and demographic histories of critically endangered Fraxinus (ash) species.Communications biology · 2024Article
- Chromosome-scale genome assembly ofFrontiers in plant science · 2024Article
- Complete chloroplast genome ofMitochondrial DNA. Part B, Resources · 2024Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlants exhibit wide chemical diversity due to the production of specialized metabolites that function as pollinator attractants, defensive compounds, and signaling molecules. Lamiaceae (mints) are known for their chemodiversity and have been cultivated for use as culinary herbs, as well as sources of insect repellents, health-promoting compounds, and fragrance.
findingsWe report the chromosome-scale genome assembly of Callicarpa americana L. (American beautyberry), a species within the early-diverging Callicarpoideae clade of Lamiaceae, known for its metallic purple fruits and use as an insect repellent due to its production of terpenoids. Using long-read sequencing and Hi-C scaffolding, we generated a 506.1-Mb assembly spanning 17 pseudomolecules with N50 contig and N50 scaffold sizes of 7.5 and 29.0 Mb, respectively. In all, 32,164 genes were annotated, including 53 candidate terpene synthases and 47 putative clusters of specialized metabolite biosynthetic pathways. Our analyses revealed 3 putative whole-genome duplication events, which, together with local tandem duplications, contributed to gene family expansion of terpene synthases. Kolavenyl diphosphate is a gateway to many of the bioactive terpenoids in C. americana; experimental validation confirmed that CamTPS2 encodes kolavenyl diphosphate synthase. Syntenic analyses with Tectona grandis L. f. (teak), a member of the Tectonoideae clade of Lamiaceae known for exceptionally strong wood resistant to insects, revealed 963 collinear blocks and 21,297 C. americana syntelogs.
conclusionsAccess to the C. americana genome provides a road map for rapid discovery of genes encoding plant-derived agrichemicals and a key resource for understanding the evolution of chemical diversity in Lamiaceae.
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