ArticleCancer medicine2020
Prevalence and severity of long-term physical, emotional, and cognitive fatigue across 15 different cancer entities.
Article in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03318224 (Fatigue in Germany - Examination of Prevalence, Severity, and State of Screening and Treatment), which is not on this map. Cited by 29 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fatigue in Germany - Examination of Prevalence, Severity, and State of Screening and Treatment
Who cites it
29 citing papers in PubMed, 6 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- One out of four patients with pancreatic cancer experience psychological symptoms: A systematic review and meta-analysis.PloS one · 2026Pooled it
- Yoga for fatigue in people with cancer.The Cochrane database of systematic reviews · 2025Pooled it
- Cardiovascular training for fatigue in people with cancer.The Cochrane database of systematic reviews · 2025Pooled it
- Resistance training for fatigue in people with cancer.The Cochrane database of systematic reviews · 2024Pooled it
- Cardiovascular training versus resistance training for fatigue in people with cancer.The Cochrane database of systematic reviews · 2024Pooled it
- Effects of resistance training on quality of life, fatigue, and pain in patients undergoing cancer treatment: A systematic review and dose-response meta-analysis.Brazilian journal of physical therapyPooled it
- Impact of radiotherapy on quality of life reported by elderly patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Cancer Related Fatigue and its Association with Depression and Anxiety in the Patients with Advanced Gastric Cancer.Journal of gastrointestinal cancer · 2026Article
- Global research trends and hotspots in breast cancer related fatigue: a bibliometric investigation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Article
- The metabolic basis of cancer-related fatigue.Neuroscience and biobehavioral reviews · 2025Review
- Resourcefulness training on cancer-related fatigue and fear of cancer recurrence in patients undergoing colorectal cancer chemotherapy: a quasi-experimental study.Frontiers in public health · 2025Article
- Measures of Work-life Balance and Interventions of Reasonable Accommodations for the Return to Work of Cancer Survivors: A Scoping Review.Safety and health at work · 2024Article
- Article
- Cancer-related fatigue and activities of daily living: lessons learned from the COVID-19 pandemic.BMC palliative care · 2024Observational
- The Mechanisms Underlying the Beneficial Impact of Aerobic Training on Cancer-Related Fatigue: A Conceptual Review.Cancers · 2024Review
- Patient-physician communication about cancer-related fatigue: a survey of patient-perceived barriers.Journal of cancer research and clinical oncology · 2024Article
- Effects of Exercise Training on Patient-Specific Outcomes in Pancreatic Cancer Patients: A Scoping Review.Cancers · 2023Article
- Longitudinal changes of health-related quality of life over 10 years in breast cancer patients treated with radiotherapy following breast-conserving surgery.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Cancer survivors and adverse work outcomes: associated factors and supportive interventions.British medical bulletin · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFatigue prevalence and severity have been assessed in a variety of studies, yet, not in a standardized way, and predominantly in breast cancer patients. Systematic, comparative investigations across a broad range of cancer entities are lacking.
methodsThe FiX study systematically enrolled 2244 cancer patients across 15 entities approximately 2 years after diagnosis. Fatigue was assessed with the multidimensional EORTC QLQ-FA12 questionnaire. Physical, emotional, cognitive, and total fatigue were compared across entities and with normative values of the general population. Differences in patients' characteristics and cancer therapy between entities were taken into account using analyses of covariance models.
resultsAcross all entities, mean physical fatigue levels were significantly higher than age- and sex-matched means of the general population for all cancer entities (all Bonferroni-Holm adjusted P < .01). For most entities also emotional and cognitive fatigue levels were significantly higher than normative values. Age- and sex-standardized physical fatigue prevalence ranged from 31.8% among prostate to 51.7% among liver cancer patients. Differences between entities could not be fully explained by sex, age, BMI, or cancer therapy. Adjusted for these factors, mean physical fatigue was higher for stomach (P = .0004), lung (P = .034), kidney (P = .0011), pancreas (P = .081), and endometrium (P = .022) compared to breast cancer patients. Adjusted means of emotional fatigue were also lowest in breast cancer patients and significantly higher in stomach (P = .0047), bladder (P = .0036), and rectal (P = .0020) cancer patients.
conclusionsPhysical, emotional, and cognitive fatigue is prevalent in all 15 investigated cancer entities even 2 years after diagnosis. Fatigue in breast cancer patients, the so-far most studied group, is in the lowest range among all entities, suggesting that the extent of fatigue is still insufficiently determined. Entity-specific problems might need to be considered in the treatment of fatigue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.