Evidence map›Paper›PMID 32893474›Full record

ReviewAdvanced healthcare materials2021

Responsive Polymer Brush Design and Emerging Applications for Nanotheranostics.

Danyang Li, Lizhou Xu, Jing Wang, Julien E Gautrot

Open access · hybridAbstract readReview
In one paragraph

Review in Advanced healthcare materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 111 citations in OpenAlex.

  1. Article
  2. Article
  3. Stimuli-Responsive Supramolecular Biomaterials for Cancer Theranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. The Effective Charge of Low-Fouling Polybetaine Brushes.Langmuir : the ACS journal of surfaces and colloids · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Salt-Controlled Vertical Segregation of Mixed Polymer Brushes.International journal of molecular sciences · 2024
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Danyang LiSchool of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London, SE1 9NH, UK.
Lizhou XuDepartment of Materials, Imperial College London, London, SW7 2AZ, UK.
Jing WangSchool of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, China.
Julien E GautrotInstitute of Bioengineering, Queen Mary, University of London, Mile End Road, London, E1 4NS, UK.ORCID 0000-0002-1614-2578
Queen Mary University of London · GBImperial College London · GBNorthwestern Polytechnical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Responsive polymer brushes are a category of polymer brushes that are capable of conformational and chemical changes in response to external stimuli. They offer unique opportunities for the control of bio-nano interactions due to the precise control of chemical and structural parameters such as the brush thickness, density, chemistry, and architecture. The design of responsive brushes at the surface of nanomaterials for theranostic applications has developed rapidly. These coatings can be generated from a very broad range of nanomaterials, without compromising their physical, photophysical, and imaging properties. Although the use of responsive brushes for nanotheranostic remains in its early stages, in this review, the aim is to present how the systems developed to date can be combined to control sensing, imaging, and controlled delivery of therapeutics. The recent developments for such design and associated methods for the synthesis of responsive brushes are discussed. The responsive behaviors of homo polymer brushes and brushes with more complex architectures are briefly reviewed, before the applications of responsive brushes as smart delivery systems are discussed. Finally, the recent work is summarized on the use of responsive polymer brushes as novel biosensors and diagnostic tools for the detection of analytes and biomarkers.

Indexed as

Biosensing TechniquesNanostructuresPolymersTheranostic NanomedicinePolymersbiosensingdiagnosisdrug deliverynanomaterialsnanotheranosticspolymer brushes

Identifiers

PMID32893474
PMCPMC11468394
OpenAlexW3083800593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.