Observational studyJournal of clinical laboratory analysis2020
Predictive criteria of severe cases in COVID-19 patients of early stage: A retrospective observational study.
Observational study in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Chronic Diseases as a Predictor for Severity and Mortality of COVID-19: A Systematic Review With Cumulative Meta-Analysis.Frontiers in medicine · 2021Pooled it
- ISW-LM: An intensive symptom weight learning mechanism for early COVID-19 diagnosis.Computers in biology and medicine · 2022Article
- Heterogeneity and Risk of Bias in Studies Examining Risk Factors for Severe Illness and Death in COVID-19: A Systematic Review and Meta-Analysis.Pathogens (Basel, Switzerland) · 2022Review
- Prognostic factors for predicting severity and mortality in hospitalized COVID-19 patients.Journal of clinical laboratory analysis · 2022Article
- A new screening tool for SARS-CoV-2 infection based on self-reported patient clinical characteristics: the COVBMC infectious diseases · 2022Article
- Usefulness of laboratory parameters and chest CT in the early diagnosis of COVID-19.Revista do Instituto de Medicina Tropical de Sao Paulo · 2022Article
- Gamma-glutamyl-transferase may predict COVID-19 outcomes in hospitalised patients.International journal of clinical practice · 2021Article
- Risk factors for prolonged virus shedding of respiratory tract and fecal in adults with severe acute respiratory syndrome coronavirus-2 infection.Journal of clinical laboratory analysis · 2021Article
- A simple and readily available inflammation-based risk scoring system on admission predicts the need for mechanical ventilation in patients with COVID-19.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021Article
- Azithromycin and glucosamine may amplify the type 1 interferon response to RNA viruses in a complementary fashion.Immunology letters · 2020Review
- Predictive criteria of severe cases in COVID-19 patients of early stage: A retrospective observational study.Journal of clinical laboratory analysis · 2020Observational
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundPatients with coronavirus disease 2019 (COVID-19) often suffer sudden deterioration of disease around 1-2 weeks after onset. Once the disease progressed to severe phase, clinical prognosis of patients will significantly deteriorate.
methodsThis was a multicenter retrospective study on patients of all adult inpatients (≥18 years old) from Tianyou Hospital (Wuhan, China) and the Fourth Affiliated Hospital, Zhejiang University School of Medicine. All 139 patients had laboratory-confirmed COVID-19 in their early stage, which is defined as within 7 days of clinical symptoms. Univariate and multivariate logistic regression models were used to determine the predictive factors in the early detection of patients who may subsequently develop into severe cases.
resultsMultivariable logistic regression analysis showed that the higher level of hypersensitivity C-reactive protein (OR = 4.77, 95% CI:1.92-11.87, P = .001), elevated alanine aminotransferase (OR = 6.87, 95%CI:1.56-30.21, P = .011), and chronic comorbidities (OR = 11.48, 95% CI:4.44-29.66, P < .001) are the determining risk factors for the progression into severe pneumonia in COVID-19 patients.
conclusionEarly COVID-19 patients with chronic comorbidities, elevated hs-CRP or elevated ALT are significantly more likely to develop severe pneumonia as the disease progresses. These risk factors may facilitate the early diagnosis of critical patients in clinical practice.
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