ArticleGenetics in medicine : official journal of the American College of Medical Genetics2021
Predicting the risk of cardiac myxoma in Carney complex.
Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00001452 (Definition of the Genotype and Clinical Phenotype of Primary Pigmented Nodular Adrenocortical Disease), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Definition of the Genotype and Clinical Phenotype of Primary Pigmented Nodular Adrenocortical Disease (PPNAD), Carney Complex, Peutz-Jeghers Syndrome and Related Conditions
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Pooled it
- Clinical Heterogeneity of Recurrent Familial Cardiac Myxoma in PRKAR1A-Related Carney Complex.JACC. Case reports · 2026Article
- Rapid interval progression of familial atrial myxoma despite negative screening.European heart journal. Case reports · 2026Article
- ST-Segment Elevation Myocardial Infarction From Carney Complex Familial Myxoma Embolization.JACC. Case reports · 2026Article
- Article
- Early Recurrence of Cardiac Myxomas in an Adolescent With Carney Complex: Clinical Clues Preceding Imaging Findings-A Case Report.Case reports in cardiology · 2026Article
- Atrial Myxoma in Both Chambers: Biatrial or Bilateral? A Rare Case Resected via Endoscopic Approach and Literature Review.Medical sciences (Basel, Switzerland) · 2025Review
- Keeping Up With Carney Complex: A Case of Recurrent Cardiac Myxomas.JACC. Case reports · 2025Article
- Cardiac tumors: clinical presentation, diagnosis, reatment, and results.Langenbeck's archives of surgery · 2025Review
- Cardiodermatology: the heart of the connection between the skin and cardiovascular disease.Nature reviews. Cardiology · 2025Review
- Case Report: The carney complex led to the tragic passing of a young girl in the prime of her life.Frontiers in cardiovascular medicine · 2025Article
- Familial Carney complex with embolic ischemic stroke: a case report and literature review.Frontiers in oncology · 2025Article
- Case Report: Cardiac myxomas and Carney complex: a case of recurrent embolic strokes and intracranial tumor growth.Frontiers in oncology · 2025Article
- The Therapeutic Potential of Different Surgical Approaches in the Management of Cardiac Myxoma: A Systematic Review.Journal of clinical medicine · 2024Review
- Position-triggered embolic events in cardiac myxoma: a description of two cases.Quantitative imaging in medicine and surgery · 2024Article
- Bridging the gap in cardiac mass diagnosis: Advanced imaging, genetic associations, and biomarkers.World journal of clinical cases · 2024Article
- Cardiac Tumors: Review.Brazilian journal of cardiovascular surgery · 2024Review
- Cardiac myxomas: causes, presentations, diagnosis, and management.Irish journal of medical science · 2024Review
- NovelFrontiers in endocrinology · 2024Review
- Cutaneous signs of selected cardiovascular disorders: A narrative review.Open medicine (Warsaw, Poland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeCarney complex (CNC), is an autosomal dominant multiple neoplasia and lentiginosis syndrome. We aimed to identify risk factors associated with the occurrence and recurrence of cardiac myxomas, the predominant cause of death in CNC patients.
methodsPatients with CNC were monitored prospectively between 1995 and 2020 for the development of cardiac myxomas.
resultsOf the 319 patients studied, 136 (42.6%) developed myxomas. The mean age at diagnosis was 28.7 ± 16.6 years in females and 25.0 ± 16.4 years in males. By age 30, 35% of females and 45% of males had at least one myxoma. The CNC-related lesions, lentigines, cutaneous, mucosal, or breast myxomas, thyroid nodules, pituitary adenoma, and schwannoma were significantly more frequent (all p < 0.05) among patients with myxomas. Forty-four percent of patients had recurrences; nearly all within the first 8 and 16 years for males and females, respectively. Recurrences were more common in females.
conclusionThis is the largest study to date and provides the first-time risk estimates by age and gender for cardiac myxomas in CNC patients. Cardiac myxomas are common by age 30 and often recur, especially in women, but the risk drops in 10 to 20 years. These findings may guide patient counseling, screening intervals, and surgical approaches. CLINICAL
trial registrationClinical Trial Registration: Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease and the Carney complex, Registration number: NCT00001452 URL: https://clinicaltrials.gov/ct2/show/NCT00001452.
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