ArticleBMJ open2020
Epidemiology and determinants of non-diabetic hyperglycaemia and its conversion to type 2 diabetes mellitus, 2000-2015: cohort population study using UK electronic health records.
Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Risk factors for progression to type 2 diabetes in prediabetes: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Cost-effectiveness of implementing the National Health Service England Diabetes Prevention Programme in Canada: a modelling study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Article
- Real-world predictors of progression to type 2 diabetes among adults with prediabetes.Diabetes, obesity & metabolism · 2026Article
- Risk Factors for the Progression or Regression to Diabetes or Normoglycaemia for Men with Impaired Fasting Glucose.Journal of diabetes research · 2025Article
- Age- and deprivation-related inequalities in identification of people at high risk of type 2 diabetes in England.BMC public health · 2024Article
- Real-world study of the multimorbidity and health service utilisation among individuals with non-diabetic hyperglycemia and type 2 diabetes mellitus in North West London.BMJ open diabetes research & care · 2024Article
- Evaluating the Long-Term Cost-Effectiveness of the English NHS Diabetes Prevention Programme using a Markov Model.PharmacoEconomics - open · 2024Article
- A critical exploration of the diets of UK disadvantaged communities to inform food systems transformation: a scoping review of qualitative literature using a social practice theory lens.BMC public health · 2023Article
- Could diabetes prevention programmes result in the widening of sociodemographic inequalities in type 2 diabetes? Comparison of survey and administrative data for England.Journal of epidemiology and community health · 2023Article
- Evaluating Ethnic Variations in the Risk of Infections in People With Prediabetes and Type 2 Diabetes: A Matched Cohort Study.Diabetes care · 2023Article
- Referral to the NHS Diabetes Prevention Programme and conversion from nondiabetic hyperglycaemia to type 2 diabetes mellitus in England: A matched cohort analysis.PLoS medicine · 2023Observational
- Population level impact of the NHS Diabetes Prevention Programme on incidence of type 2 diabetes in England: An observational study.The Lancet regional health. Europe · 2022Article
- Pre-diabetes in the elderly and the see-saw model of paternalism.Journal of medical ethics · 2021Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesTo study the characteristics of UK individuals identified with non-diabetic hyperglycaemia (NDH) and their conversion rates to type 2 diabetes mellitus (T2DM) from 2000 to 2015, using the Clinical Practice Research Datalink.
designCohort study. SETTINGS: UK primary Care Practices.
participantsElectronic health records identified 14 272 participants with NDH, from 2000 to 2015. PRIMARY AND SECONDARY OUTCOME MEASURES: Baseline characteristics and conversion trends from NDH to T2DM were explored. Cox proportional hazards models evaluated predictors of conversion.
resultsCrude conversion was 4% within 6 months of NDH diagnosis, 7% annually, 13% within 2 years, 17% within 3 years and 23% within 5 years. However, 1-year conversion fell from 8% in 2000 to 4% in 2014. Individuals aged 45-54 were at the highest risk of developing T2DM (HR 1.20, 95% CI 1.15 to 1.25- compared with those aged 18-44), and the risk reduced with older age. A body mass index (BMI) above 30 kg/m
conclusionAlthough the rate of conversion from NDH to T2DM fell between 2010 and 2015, this is likely due to changes over time in the cut-off points for defining NDH, and more people of lower diabetes risk being diagnosed with NDH over time. People aged 45-54, smokers, depressed, with high BMI and more deprived are at increased risk of conversion to T2DM.
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