ArticleVaccine2020
Pregnant women's perceptions of risks and benefits when considering participation in vaccine trials.
Article in Vaccine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Factors influencing the participation of pregnant and lactating women in clinical trials: A mixed-methods systematic review.PLoS medicine · 2024Pooled it
- Understanding pneumococcal vaccine perceptions in seven countries: Findings from a cross-sectional survey.Human vaccines & immunotherapeutics · 2026Article
- Article
- Pregnant women's attitudes and intentions toward tuberculosis, malaria, group B streptococcus, and respiratory syncytial virus vaccines in pregnant: Findings from a cross-sectional study of pregnant women living in Brazil, Ghana, Kenya, and Pakistan.PLOS global public health · 2026Article
- Review
- The risk tolerance and decision-making processes of Australian women regarding medication trials in pregnancy.The Australian & New Zealand journal of obstetrics & gynaecology · 2025Article
- Navigating vaccination in pregnancy: Qualitative study in 21 ethnically diverse pregnant women.PloS one · 2025Article
- The inclusion of pregnant women in research during disease outbreaks globally: A scoping review.Revista latino-americana de enfermagem · 2025Article
- Understanding willingness and barriers to participate in clinical trials during pregnancy and lactation: findings from a US study.BMC pregnancy and childbirth · 2024Article
- Exploring the consent process among pregnant and breastfeeding women taking part in a maternal vaccine clinical trial in Kampala, Uganda: a qualitative study.BMC medical ethics · 2024Article
- Factors Affecting COVID-19 Vaccine Acceptance among Pregnant Women: A Cross Sectional Study from Abha City, Saudi Arabia.Vaccines · 2023Article
- Factors that impact on recruitment to vaccine trials in the context of a pandemic or epidemic: a qualitative evidence synthesis.The Cochrane database of systematic reviews · 2023Review
- Article
- It is the time to change the paradigms of pregnant and breastfeeding women in clinical research!Frontiers in pharmacology · 2023Article
- Vaccine regulation should require and enforce the inclusion of pregnant and breastfeeding women in prelicensure clinical trials.Human vaccines & immunotherapeutics · 2022Article
- The COVID-19 Vaccine Opinions of Women Planning a Pregnancy: International Web Blogs Scanning.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2022Article
- Clinical trials in pregnancy and the "shadows of thalidomide": Revisiting the legacy of Frances Kelsey.Contemporary clinical trials · 2022Article
- Article
- Physician Perspectives on Including Pregnant Women in Covid-19 Clinical Trials: Time for a Paradigm Change.Ethics & human research · 2021Article
- Appropriateness for SARS-CoV-2 vaccination for otolaryngologist and head and neck surgeons in case of pregnancy, breastfeeding, or childbearing potential: Yo-IFOS and CEORL-HNS joint clinical consensus statement.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
introductionDespite historical exclusion, there has been recent recognition of the need to address the health of pregnant women in research on vaccines against emerging pathogens. However, pregnant women's views and decision-making processes about vaccine research participation during infectious disease outbreaks remain underexplored. This study aims to examine women's decision-making processes around vaccine research participation during infectious disease outbreaks.
methodsWe conducted qualitative semi-structured in-depth interviews with pregnant and recently pregnant women (n = 13), eliciting their views on four hypothetical Zika Virus vaccine research scenarios and probing their decision-making processes around participation. After recorded interviews were transcribed, thematic analysis was conducted based on a priori and emergent themes.
resultsMost women interviewed were accepting of vaccine research scenarios. Three broad themes-evidence, risk, and trust-characterized women's decision-making processes. Women varied in how different types and levels of evidence impacted their considerations, which risks were most salient to their decision-making processes, and from whom they trusted recommendations about vaccine research participation. Exemplary quotes from each theme are presented, and lessons for vaccine development during the current COVID-19 pandemic and future outbreaks are discussed.
conclusionSome pregnant women are accepting of participation in vaccine research during infectious disease outbreaks. Incorporating their priorities into trial design may facilitate their participation and generation of evidence for this important population.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.