Evidence map›Paper›PMID 32893032›Full record

ReviewMolecular aspects of medicine2020

The Atlas of Inflammation Resolution (AIR).

Charles N Serhan, Shailendra K Gupta, Mauro Perretti, Catherine Godson, Eoin Brennan, Yongsheng Li, Oliver Soehnlein, Takao Shimizu, Oliver Werz, Valerio Chiurchiù and 20 more

Open access · hybridAbstract readReview
In one paragraph

Review in Molecular aspects of medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 1 pooled it
17.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 1 synthesis or guideline pooled it, 167 citations in OpenAlex.

  1. Pooled it
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  5. Advances in Adipose Tissue Biology.Endocrine reviews · 2026
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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 17 institutions in 11 countries.

Charles N SerhanCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Shailendra K GuptaDepartment of Systems Biology and Bioinformatics, University of Rostock, 18051, Rostock, Germany.
Mauro PerrettiThe William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Catherine GodsonDiabetes Complications Research Centre, Conway Institute & School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
Eoin BrennanDiabetes Complications Research Centre, Conway Institute & School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
Yongsheng LiDepartment of Medical Oncology, Chongqing University Cancer Hospital, Chongqing, 400030, China.
Oliver SoehnleinDepartment of Physiology and Pharmacology (FyFA), Karolinska Institutet, 17177, Stockholm, Sweden; German Center for Cardiovascular Research (DZHK), München, Germany; Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian University, 80336, München, Germany.
Takao ShimizuDepartment of Lipidomics, Graduate School of Medicine, The University of Tokyo, 113-0033 Tokyo, Japan; National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, Japan.
Oliver WerzDepartment of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, 07743, Jena, Germany.
Valerio ChiurchiùInstitute of Translational Pharmacology, National Research Council, 00133, Rome, Italy; Laboratory of Resolution of Neuroinflammation, IRCCS Santa Lucia Foundation, 00143, Rome, Italy.
Angelo AzziSchool of Graduate Biomedical Pharmacology and Drug Development Program at Tufts University, Boston, MA 02111, USA.
Marc DubourdeauAmbiotis, Canal Biotech 2 - 3 Rue des Satellites, 31400, Toulouse, France.
Suchi Smita GuptaDepartment of Systems Biology and Bioinformatics, University of Rostock, 18051, Rostock, Germany.
Patrick SchopohlDepartment of Systems Biology and Bioinformatics, University of Rostock, 18051, Rostock, Germany.
Matti HochDepartment of Systems Biology and Bioinformatics, University of Rostock, 18051, Rostock, Germany.
Dragana GjorgevikjDepartment of Systems Biology and Bioinformatics, University of Rostock, 18051, Rostock, Germany.
Faiz M KhanDepartment of Systems Biology and Bioinformatics, University of Rostock, 18051, Rostock, Germany.
David BrauerDepartment of Systems Biology and Bioinformatics, University of Rostock, 18051, Rostock, Germany.
Anurag TripathiCSIR - Indian Institute of Toxicology Research, 226001, Lucknow, India.
Konstantin CesnuleviciusDepartment of Medical Affairs & Research, Heel GmbH, 76532, Baden-Baden, Germany.
David LescheidDepartment of Medical Affairs & Research, Heel GmbH, 76532, Baden-Baden, Germany.
Myron SchultzDepartment of Medical Affairs & Research, Heel GmbH, 76532, Baden-Baden, Germany.
Eva SärndahliRiSC - Inflammatory Response and Infection Susceptibility Centre, Faculty of Medicine and Health, Örebro University, SE-701 82, Örebro, Sweden; School of Medical Sciences, Örebro University, SE-701 82, Örebro, Sweden.
Dirk RepsilberSchool of Medical Sciences, Örebro University, SE-701 82, Örebro, Sweden.
Robert KruseiRiSC - Inflammatory Response and Infection Susceptibility Centre, Faculty of Medicine and Health, Örebro University, SE-701 82, Örebro, Sweden; Department of Clinical Research Laboratory, Faculty of Medicine and Health, Örebro University, SE-701 82, Örebro, Sweden.
Angelo SalaDepartment of Pharmaceutical Sciences, University of Milan, 20133 Milano, and IRIB, C.N.R, 90146, Palermo, Italy.
Jesper Z HaeggströmDepartment of Medical Biochemistry and Biophysics, Karolinska Institute, SE-171 77, Stockholm, Sweden.
Bruce D LevyBrigham and Women's Hospital, Department of Medicine, Pulmonary and Critical Care Medicine and Harvard Medical School, Boston, MA, 02115, USA.
János G FilepDepartment of Pathology and Cell Biology, University of Montreal, and Research Center, Maisonneuve-Rosemont Hospital, Montreal, QC, H1T 2M4, Canada.
Olaf WolkenhauerDepartment of Systems Biology and Bioinformatics, University of Rostock, 18051, Rostock, Germany; Stellenbosch Institute for Advanced Study (STIAS), Wallenberg Research Centre at Stellenbosch University, Stellenbosch, South Africa. Electronic address: olaf.wolkenhauer@uni-rostock.de.
University of Rostock · DEHeel (Germany) · DETufts University · USUniversity College Dublin · IEBrigham and Women's Hospital · USChongqing Cancer Hospital · CNFriedrich Schiller University Jena · DEGerman Centre for Cardiovascular Research · DEHarvard University · USIndian Institute of Toxicology Research · INIstituto di Farmacologia Traslazionale · ITKarolinska Institutet · SENational Center for Global Health and Medicine · JPÖrebro University · SEParis Biotech Santé · FRUniversité de Montréal · CAWilliam Harvey Research Institute · GB

Funding

Resolution Mechanisms in Acute Inflammation: Resolution PharmacologyP01GM095467 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI PETASIS, NICOS A · 2011 to 2020
$14.8M
BLOOD CELL LIPOXYGENASE PRODUCTS: FORMATION AND ACTIONR01GM038765 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SERHAN, CHARLES NICHOLAS · 1992 to 2020
$4.9M
Specialized Pro-Resolving Mediators in AsthmaR01HL122531 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEVY, BRUCE D · 2014 to 2024
$4.7M
CIHR MOP-102619CIHR MOP-97742Medical Research Council MR/K013068/1NHLBI NIH HHS R01 HL122531NIGMS NIH HHS P01 GM095467NIGMS NIH HHS R01 GM038765Versus Arthritis 21274
6 · The paper itself

Abstract

Acute inflammation is a protective reaction by the immune system in response to invading pathogens or tissue damage. Ideally, the response should be localized, self-limited, and returning to homeostasis. If not resolved, acute inflammation can result in organ pathologies leading to chronic inflammatory phenotypes. Acute inflammation and inflammation resolution are complex coordinated processes, involving a number of cell types, interacting in space and time. The biomolecular complexity and the fact that several biomedical fields are involved, make a multi- and interdisciplinary approach necessary. The Atlas of Inflammation Resolution (AIR) is a web-based resource capturing an essential part of the state-of-the-art in acute inflammation and inflammation resolution research. The AIR provides an interface for users to search thousands of interactions, arranged in inter-connected multi-layers of process diagrams, covering a wide range of clinically relevant phenotypes. By mapping experimental data onto the AIR, it can be used to elucidate drug action as well as molecular mechanisms underlying different disease phenotypes. For the visualization and exploration of information, the AIR uses the Minerva platform, which is a well-established tool for the presentation of disease maps. The molecular details of the AIR are encoded using international standards. The AIR was created as a freely accessible resource, supporting research and education in the fields of acute inflammation and inflammation resolution. The AIR connects research communities, facilitates clinical decision making, and supports research scientists in the formulation and validation of hypotheses. The AIR is accessible through https://air.bio.informatik.uni-rostock.de.

Indexed as

InflammationInflammation MediatorsHomeostasisHumansInflammation MediatorsAcute inflammationDisease mapInflammation resolutionInflammatory mediatorsMolecular interaction mapMolecular switchesPro-resolving mediatorsSystems biology

Identifiers

PMID32893032
PMCPMC7733955
OpenAlexW3082216319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.