Evidence map›Paper›PMID 32892746›Full record

Observational studyLipids in health and disease2020

Low high-density lipoprotein level is correlated with the severity of COVID-19 patients: an observational study.

Guyi Wang, Quan Zhang, Xianmei Zhao, Haiyun Dong, Chenfang Wu, Fang Wu, Bo Yu, Jianlei Lv, Siye Zhang, Guobao Wu and 4 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Lipids in health and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 9 pooled it
3.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 9 syntheses or guidelines pooled it, 173 citations in OpenAlex.

  1. Pediatric endocrinopathies related to COVID-19: an update.World journal of pediatrics : WJP · 2023
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  10. The physiological effects of APOE genotype in healthy young/middle-aged individuals.Biological reviews of the Cambridge Philosophical Society · 2026
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  19. Pathogenic mechanisms of cardiovascular damage in COVID-19.Molecular medicine (Cambridge, Mass.) · 2024
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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Guyi WangDepartment of Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Quan ZhangDepartment of Critical Care Medicine, the First Hospital of Changsha, Changsha, 410011, China.
Xianmei ZhaoDepartment of Physical Examination Center, the Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Haiyun DongDepartment of Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Chenfang WuDepartment of Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Fang WuDepartment of Oncology, the Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Bo YuDepartment of Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Jianlei LvDepartment of Critical Care Medicine, the First Hospital of Changsha, Changsha, 410011, China.
Siye ZhangDepartment of Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Guobao WuDepartment of Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Shangjie WuDepartment of Respiratory, the Second Xiangya Hospital, Central South University, Changsha, China.
Xiaolei WangDepartment of Physical Examination Center, the Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Ying WuDepartment of Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, 410011, China. biovivian@csu.edu.cn.
Yanjun ZhongDepartment of Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, 410011, China. zhongyanjun@csu.edu.cn.ORCID http://orcid.org/0000-0003-4238-0112
Central South University · CNThe First Hospital of Changsha · CN

Funding

Emergency project for COVID-19 prevention and control of Central South University, China 160260005
6 · The paper itself

Abstract

backgroundThe purpose of the study is to describe the blood lipid levels of patients diagnosed with coronavirus disease 2019 (COVID-19) and to analyze the correlation between blood lipid levels and the prognosis of COVID-19 patients.

methodsIn the clinical retrospective analysis, a total of 228 adults infected with COVID-19 were enrolled between January 17, 2020 and March 14, 2020, in Changsha, China. One thousand one hundred and forty healthy participants with matched age and gender were used as control. Median with interquartile range and Mann-Whitney test were adopted to describe and analyze clinical data. The Kaplan-Meier (KM) curve and Cox regression analysis were used to analyze the correlation between high-density lipoprotein cholesterol (HDL-C) and the severity of COVID-19.

resultsCompared with control, COVID-19 patients showed significantly lower levels of total cholesterol (TC) [median, 3.76 vs 4.65 mmol/L, P = 0.031], triglyceride [median, 1.08 vs 1.21 mmol/L, P <  0.001], low-density lipoprotein cholesterol (LDL-C) [median, 2.63 vs 2.83 mmol/L, P <  0.001], and HDL-C [median, 0.78 vs 1.37 mmol/L, P <  0.001], while compared with non-severe patients, severe COVID-19 patients only presented lower levels of HDL-C [median, 0.69 vs 0.79 mmol/L, P = 0.032]. In comparison with patients with high HDL-C, patients with low HDL-C showed a higher proportion of male (69.57% vs 45.60%, P = 0.004), higher levels of C-reactive protein (CRP) (median, 27.83 vs 12.56 mg/L, P <  0.001) and higher proportion of severe events (36.96% vs 14.84%, P = 0.001). Moreover, patients with low HDL-C at admission showed a higher risk of developing severe events compared with those with high HDL-C (Log Rank P = 0.009). After adjusting for age, gender and underlying diseases, they still had elevated possibility of developing severe cases than those with high HDL-C (HR 2.827, 95% CI 1.190-6.714, P = 0.019).

conclusionsHDL-C level was lower in COVID-19 adult patients, and low HDL-C in COVID-19 patients was correlated with a higher risk of developing severe events.

Indexed as

BetacoronavirusAdultChinaCholesterolCholesterol, HDLCholesterol, LDLCoronavirus InfectionsCOVID-19C-Reactive ProteinFemaleHumansMaleMiddle AgedPandemicsPneumonia, ViralRetrospective StudiesCholesterolCholesterol, HDLCholesterol, LDLC-Reactive ProteinTriglyceridesAdultCOVID-19High-density lipoprotein cholesterolLipoproteinsPrognosisSevere acute respiratory syndrome coronavirus 2

Identifiers

PMID32892746
PMCPMC7475024
OpenAlexW3083613611

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.