Evidence map›Paper›PMID 32892692›Full record

ArticleAdipocyte2020

Adipocyte ADAM17 plays a limited role in metabolic inflammation.

Joseph C Lownik, Jared S Farrar, Janina V Pearce, Francesco S Celi, Rebecca K Martin

Open access · goldAbstract read
In one paragraph

Article in Adipocyte, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Myeloid ADAM17 induces ST2Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
    Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Joseph C LownikCenter for Clinical and Translational Research, Virginia Commonwealth University School of Medicine , Richmond, VA, USA.ORCID 0000-0002-9025-8210
Jared S FarrarCenter for Clinical and Translational Research, Virginia Commonwealth University School of Medicine , Richmond, VA, USA.ORCID 0000-0001-7865-6526
Janina V PearceCenter for Clinical and Translational Research, Virginia Commonwealth University School of Medicine , Richmond, VA, USA.
Francesco S CeliDepartment of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Virginia Commonwealth University School of Medicine , Richmond, VA, USA.ORCID 0000-0001-7218-7052
Rebecca K MartinDepartment of Microbiology and Immunology, Virginia Commonwealth University School of Medicine , Richmond, VA, USA.ORCID 0000-0001-9948-5463
Virginia Commonwealth University · US

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Keri R Maher · 1985 to 2026
$51.0M
Virginia Commonwealth University Postbaccalaureate Research Education ProgramR25GM089614 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI Rebecca Kelley Martin · 2010 to 2026
$4.9M
IL-25 as a master regulator of extrafollicular benign IgER56AI139658 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI MARTIN, REBECCA KELLEY · 2019 to 2019
$380k
NCI NIH HHS P30 CA016059NIAID NIH HHS R56 AI139658NIGMS NIH HHS R25 GM089614
6 · The paper itself

Abstract

The role of ADAM17, its substrates, and its natural inhibitor has been well studied in the context of inflammation, including metabolic inflammation, with mixed results. Previous studies examining global

Indexed as

Energy MetabolismADAM17 ProteinAdipocytesAnimalsBiomarkersCytokinesDiet, High-FatDisease Models, AnimalDisease SusceptibilityFemaleImmunophenotypingInflammationInflammation MediatorsMaleMiceADAM17 ProteinAdam17 protein, mouseBiomarkersCytokinesInflammation MediatorsADAM17adipocytehigh-fat dietmetabolic inflammationproteaseTNF

Identifiers

PMID32892692
PMCPMC7714430
OpenAlexW3083293944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.