Evidence map›Paper›PMID 32892676›Full record

ArticleEpigenetics2021

DNA methylation profiles unique to Kalahari KhoeSan individuals.

Alexander Goncearenco, Brenna A LaBarre, Hanna M Petrykowska, Weerachai Jaratlerdsiri, M S Riana Bornman, Stephen D Turner, Vanessa M Hayes, Laura Elnitski

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Alexander GoncearencoGenomic Functional Analysis Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Brenna A LaBarreGenomic Functional Analysis Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Hanna M PetrykowskaGraduate Program in Bioinformatics, Boston University, Boston, MA, USA.
Weerachai JaratlerdsiriLaboratory for Human Comparative & Prostate Cancer Genomics, Garvan Institute of Medical Research, Darlinghurst, Australia.
M S Riana BornmanSchool of Health Systems and Public Health, University of Pretoria, Pretoria, South Africa.
Stephen D TurnerDivision of Biomedical Informatics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Vanessa M HayesLaboratory for Human Comparative & Prostate Cancer Genomics, Garvan Institute of Medical Research, Darlinghurst, Australia.ORCID 0000-0002-4524-7280
Laura ElnitskiGenomic Functional Analysis Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-1065-019X
Boston University · USNational Institutes of Health · USGarvan Institute of Medical Research · AUThe University of Sydney · AUUniversity of Pretoria · ZAUniversity of Virginia · US

Funding

Regulatory and epigenetic landscapes reveal biological processes, disease mechanisms and diagnostic markersZIAHG200323 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ELNITSKI, LAURA L · 2009 to 2025
$27.6M
6 · The paper itself

Abstract

Genomes of KhoeSan individuals of the Kalahari Desert provide the greatest understanding of single nucleotide diversity in the human genome. Compared with individuals in industrialized environments, the KhoeSan have a unique foraging and hunting lifestyle. Given these dramatic environmental differences, and the responsiveness of the methylome to environmental exposures of many types, we hypothesized that DNA methylation patterns would differ between KhoeSan and neighbouring agropastoral and/or industrial Bantu. We analysed Illumina HumanMethylation 450 k array data generated from blood samples from 38 KhoeSan and 42 Bantu, and 6 Europeans. After removing CpG positions associated with annotated and novel polymorphisms and controlling for white blood cell composition, sex, age and technical variation we identified 816 differentially methylated CpG loci, out of which 133 had an absolute beta-value difference of at least 0.05. Notably

Indexed as

Cation Transport ProteinsCpG IslandsDNA MethylationEpigenesis, GeneticBlack PeopleBotswanaEthnicityGenome, HumanHumansWhite PeopleCation Transport ProteinsSLC39A4 protein, humanepigenomeIllumina methylation arrayKhoesanMethylationmethylation probessingle nucleotide variants

Identifiers

PMID32892676
PMCPMC8078743
OpenAlexW3083829973

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.