Evidence map›Paper›PMID 32892471›Full record

ArticleEuropean journal of heart failure2021

National trends in heart failure mortality in men and women, United Kingdom, 2000-2017.

Clare J Taylor, José M Ordóñez-Mena, Nicholas R Jones, Andrea K Roalfe, Sarah Lay-Flurrie, Tom Marshall, F D Richard Hobbs

Registry-linked trialAbstract read
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In one paragraph

Article in European journal of heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05416879 (Lifestyle Behaviours of Women Newly Diagnosed With Heart Failure), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05416879 recruitingnot on this mapstarted 2022, after this paper: background citation

Lifestyle Behaviours of Women Newly Diagnosed With Heart Failure: A Quantitative and Qualitative Approach

TypeobservationalSponsorNewcastle UniversityRan2022 to 2026Enrolled40ConditionsHeart FailureArmsActigraph GT3X+BT
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pivotal Trials in Heart Failure in 2024-Putting Evidence into Clinical Practice!The International journal of angiology : official publication of the International College of Angiology, Inc · 2026
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  17. Predictors of mortality in heart failure patients with reduced or mildly reduced Ejection Fraction: The CASABLANCA HF Study.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Clare J TaylorNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
José M Ordóñez-MenaNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Nicholas R JonesNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Andrea K RoalfeNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Sarah Lay-FlurrieNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Tom MarshallInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
F D Richard HobbsNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

Funding

Collaboration for Leadership in Applied Health Research and Care (CLAHRC) OxfordNational Institute for Health ResearchWellcome TrustWellcome Trust 203921/Z/16/Z
6 · The paper itself

Abstract

aimsTo understand gender differences in the prognosis of women and men with heart failure, we compared mortality, cause of death and survival trends over time. METHODS AND

resultsWe analysed UK primary care data for 26 725 women and 29 234 men over age 45 years with a new diagnosis of heart failure between 1 January 2000 and 31 December 2017 using the Clinical Practice Research Datalink, inpatient Hospital Episode Statistics and the Office for National Statistics death registry. Age-specific overall survival and cause-specific mortality rates were calculated by gender and year. During the study period 15 084 women and 15 822 men with heart failure died. Women were on average 5 years older at diagnosis (79.6 vs. 74.8 years). Median survival was lower in women compared to men (3.99 vs. 4.47 years), but women had a 14% age-adjusted lower risk of all-cause mortality [hazard ratio (HR) 0.86, 95% confidence interval (CI) 0.84-0.88]. Heart failure was equally likely to be cause of death in women and men (HR 1.03, 95% CI 0.96-1.12). There were modest improvements in survival for both genders, but these were greater in men. The reduction in mortality risk in women was greatest for those diagnosed in the community (HR 0.83, 95% CI 0.80-0.85).

conclusionsWomen are diagnosed with heart failure older than men but have a better age-adjusted prognosis. Survival gains were less in women over the last two decades. Addressing gender differences in heart failure diagnostic and treatment pathways should be a clinical and research priority.

Indexed as

Heart FailureFemaleHospitalizationHumansMaleMiddle AgedProportional Hazards ModelsRisk FactorsSex FactorsUnited KingdomGenderHeart failureMortalityPrognosisSexSurvival

Identifiers

PMID32892471
PMCPMC8287578

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.