Evidence map›Paper›PMID 32892463›Full record

ArticleBrain and behavior2020

Benefit and risk of early intravenous heparin after thrombolysis in patients with acute ischemic stroke.

Xu Tong, Yibin Cao, Wenzhi Wang, David Wang, Yongjun Wang, Yilong Wang, Thrombolysis Implementation, Monitor of Acute Ischemic Stroke in China (TIMS-China) Investigators

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Xu TongDepartment of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-3277-6941
Yibin CaoDepartment of Neurology, Tangshan Gongren Hospital, Hebei Medical University, Tangshan, China.
Wenzhi WangBeijing Neurosurgical Institute, Capital Medical University, Beijing, China.
David WangIllinois Neurological Institute Stroke Network, Sisters of the Third Order of St Francis Healthcare System, University of Illinois College of Medicine, Peoria, IL, USA.
Yongjun WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yilong WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Thrombolysis Implementation, Monitor of Acute Ischemic Stroke in China (TIMS-China) Investigators
Capital Medical University · CNHebei Medical University · CNIllinois College · US

Funding

Beijing Excellent Talents Training and Supporting- Top Youth Team by Beijing Municipal Science and Technology Commission 2016000021223TD03Beijing Outstanding Young Scientist Program BJJWZYJH01201910025030Beijing Science and Technology Plan by Beijing Municipal Science and Technology Commission D171100003017001China Postdoctoral Science Foundation 2019M650773Hebei Provincial Health and Family Planning Commission 20181258National Natural Science Foundation of China 81825007"Thirteenth-Five" Key Development and Research Plan by the Ministry of Science and Technology of the People's Republic of China 2017YFC1307900Youth Beijing Scholar Program, Beijing Talent Project - Class A: Innovation and Development 2018A12
6 · The paper itself

Abstract

background and purposeWe performed a retrospective analysis of the "Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China)" registry to explore the benefit and risk of intravenous thrombolysis (IVT) followed by intravenous heparin (IVH) in acute ischemic stroke (AIS) patients.

methodsIn the TIMS-China database, the patients who received IVH immediately after IVT (Early IVH group) and those who initiated antithrombotic therapy (ATT) until 24 hr after IVT (Standard ATT group) were screened for this comparison. Propensity score (PS) matching was performed between both groups. The logistic regression analysis was performed in the matched population to compare all the efficacy and safety outcomes.

resultsOf 1,437 patients in this study, 119 received early IVH and 1,318 cases initiated standard ATT. After PS matching (1:2), 117 pairs were identified. The early IVH group had higher proportions of neurological improvement at 24 hr (OR = 2.24, 95% CI = 1.42-3.53) and 7 days (OR = 1.92, 95% CI = 1.22-3.03), better chance of excellent recovery (OR = 1.69, 95% CI = 1.07-2.67) and functional independence (OR = 1.77, 95% CI = 1.13-2.78) at 90 days, and a lower 90-day mortality (OR = 0.44, 95% CI = 0.21-0.92) than standard ATT group. Additionally, early IVH did not increase the risk of symptomatic intracranial hemorrhage (OR = 0.92, 95% CI = 0.34-2.48).

conclusionsIVH immediately after thrombolysis seems to be safe and potentially more effective as compared with standard ATT delay of 24 hr for a subset of AIS patients.

Indexed as

Brain IschemiaIschemic StrokeStrokeChinaFibrinolytic AgentsHeparinHumansRetrospective StudiesThrombolytic TherapyTissue Plasminogen ActivatorTreatment OutcomeFibrinolytic AgentsHeparinTissue Plasminogen Activatoranticoagulationheparinischemic strokethrombolysistissue plasminogen activator

Identifiers

PMID32892463
PMCPMC7559612
OpenAlexW3083313582

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.