Evidence map›Paper›PMID 32892384›Full record

ArticleJournal of cellular physiology2021

Involvement of oxidative stress-induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis.

Run-Ze Yang, Wen-Ning Xu, Huo-Liang Zheng, Xin-Feng Zheng, Bo Li, Lei-Sheng Jiang, Sheng-Dan Jiang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed
19.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 219 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article

75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Run-Ze YangDepartment of Clinic of Spine Center, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Wen-Ning XuDepartment of Clinic of Spine Center, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Huo-Liang ZhengDepartment of Clinic of Spine Center, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Xin-Feng ZhengDepartment of Clinic of Spine Center, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Bo LiDepartment of Clinic of Spine Center, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Lei-Sheng JiangDepartment of Clinic of Spine Center, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Sheng-Dan JiangDepartment of Clinic of Spine Center, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.ORCID 0000-0001-6653-1881
Shanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis is a necrotic form of regulated cell death that was associated with lipid peroxidation and free iron-mediated Fenton reactions. It has been reported that iron deficiency had been implicated in the pathogenesis of intervertebral disc degeneration (IVDD) by activating apoptosis. However, the role of ferroptosis in the process of IVDD has not been illuminated. Here, we demonstrate the involvement of ferroptosis in IVDD pathogenesis. Our in vitro models show the changes in protein levels of ferroptosis marker and enhanced lipid peroxidation level during oxidative stress. Safranin O staining, hematoxylin-eosin staining, and immunohistochemical were used to assess the IVDD after 8 weeks of surgical procedure in vivo. Treatment with ferrostatin-1, deferoxamine, and RSL3 demonstrate the role of ferroptosis in tert-butyl hydroperoxide (TBHP)-treated annulus fibrosus cells (AFCs) and nucleus pulposus cells (NPCs). Ferritinophagy, nuclear receptor coactivator 4 (NCOA4)-mediated ferritin selective autophagy, is originated during the process of ferroptosis in response to TBHP treatment. Knockdown and overexpression NCOA4 further prove TBHP may induce ferroptosis of AFCs and NPCs in an autophagy-dependent way. These findings support a role for oxidative stress-induced ferroptosis in the pathogenesis of IVDD.

Indexed as

FerroptosisOxidative StressAnimalsAnnulus FibrosusAutophagyCarbolinesCase-Control StudiesCells, CulturedDeferoxamineDisease Models, AnimalHumansIntervertebral Disc DegenerationLipid PeroxidationMaleNuclear Receptor CoactivatorsNucleus PulposusCarbolinesDeferoxamineNcoa4 protein, ratNuclear Receptor CoactivatorsRSL3 compoundSiderophorestert-ButylhydroperoxideFerroptosisintervertebral disc degenerationNCOA4oxidative stress

Identifiers

PMID32892384
PMCPMC7891651
OpenAlexW3083501626

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.