Evidence map›Paper›PMID 32892317›Full record

Trial reportJournal of endocrinological investigation2021

Cardiometabolic health, visceral fat and circulating irisin levels: results from a real-world weight loss study.

T Miazgowski, A Kaczmarkiewicz, B Miazgowski, J Kopeć

Open access · hybridAbstract readPragmatic Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of endocrinological investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

T MiazgowskiDepartment of Propedeutics of Internal Diseases and Arterial Hypertension, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252, Szczecin, Poland. miazgowski@interia.pl.ORCID http://orcid.org/0000-0002-4819-9376
A KaczmarkiewiczPomeranian Medical University in Szczecin, Szczecin, Poland.
B MiazgowskiPomeranian Medical University in Szczecin, Szczecin, Poland.
J KopećDivision of Epidemiology, Biostatistics and Public Health Practice, University of British Columbia, Vancouver, BC, Canada.
Pomeranian Medical University · PLUniversity of British Columbia · CA

Funding

Pomorski Uniwersytet Medyczny W Szczecinie MB-315-201/16
6 · The paper itself

Abstract

backgroundThe aim of this pragmatic intervention study was to investigate changes in cardiometabolic outcomes, irisin plasma concentration, and body composition during a 4-month intervention in unselected obese individuals. MATERIALS AND

methodsIn 111 obese women aged 36.73 ± 7.2 years, we measured changes in weight, lipid profiles, glucose, insulin, Homeostatic Model Assessment-Insulin Resistance Index (HOMA-IR), uric acid, aminotransferases, and irisin. Body composition including lean mass (LM) and total (TF), gynoid (GF), android (AF), and visceral fat (VF) was assessed using densitometry. Physical activity was assessed using the International Physical Activity Questionnaire (IPAQ). The participants received tailored written advice targeting lifestyle according to current guidelines. At follow-up, patients rated their adherence in the self-administered questionnaire.

resultsMean weight loss in the whole group was 3.12 kg (- 3.3%); 26% of the women achieved the desired target of weight loss (> 5% of the initial weight), whereas weight decreased moderately in 50% and increased in 14%. In 86 women with weight loss, there were significant changes in HOMA-IR (- 13.8%), insulin (- 11.2%), alanine aminotransferase (- 8.0%), VF (- 7.0%), AF (- 5.4%), TF (- 4.7%), GF (- 2.8%) and LM (- 1.5%), whereas irisin and HDL-C levels and the mean IPAQ score did not change.

conclusionsIn this real-world evidence study, a successful weight loss achieved only 26% of patients, with overall much better adherence to diet restriction than to exercise. However, even mild to moderate weight loss resulted in significant improvements in cardiometabolic health. Weight loss was associated with a modest LM decrease but did not influence plasma irisin.

Indexed as

Diet TherapyObesityRisk Reduction BehaviorAdultBlood GlucoseBody CompositionBody Mass IndexCardiometabolic Risk FactorsCardiovascular DiseasesDensitometryExerciseFemaleFibronectinsHumansInsulinOutcome Assessment, Health CareBlood GlucoseFibronectinsFNDC5 protein, humanInsulinCardiometabolic healthIrisinReal-world studyWeight loss

Identifiers

PMID32892317
PMCPMC8124056
OpenAlexW3083711582

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.