Evidence map›Paper›PMID 32892310›Full record

ArticleEndocrine2020

Thioredoxin-interacting protein: a critical link between autophagy disorders and pancreatic β-cell dysfunction.

Wenzhen Deng, Yang Li, Ziyu Ren, Qirui He, Yanjun Jia, Yongjian Liu, Weiwei Zhang, Xianfeng Gan, Dongfang Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Endocrine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Pirfenidone ameliorates liver steatosis by targeting the STAT3-SCD1 axis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Article
  7. Thioredoxin-Interacting Protein in Cancer and Diabetes.Antioxidants & redox signaling · 2022
    Review
  8. Article
  9. Autophagy in the Neuronal Ceroid Lipofuscinoses (Batten Disease).Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Wenzhen Deng *Department of Endocrinology, The Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China.
Yang Li *Department of Endocrinology, The Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China.
Ziyu Ren *Department of Endocrinology, The Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China.
Qirui HeDepartment of Endocrinology, The Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China.
Yanjun JiaDepartment of Endocrinology, The Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China.
Yongjian LiuDepartment of Endocrinology, The Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China.
Weiwei ZhangDepartment of Endocrinology, The Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China.
Xianfeng GanDepartment of Hepatobiliary Surgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, 610072, Chengdu, China. 2544017991@qq.com.
Dongfang LiuDepartment of Endocrinology, The Second Affiliated Hospital of Chongqing Medical University, 400010, Chongqing, China. 300306@hospital.cqmu.edu.cn.ORCID http://orcid.org/0000-0002-8801-2190
Dalian Medical University · CNSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital · CN

Funding

the National Natural Science Foundation of China 81370467
6 · The paper itself

Abstract

Thioredoxin-interacting protein (TXNIP) is a known important regulatory protein of islet β-cell biology and function, but the detailed mechanism is not clear. Autophagy plays a pivotal role in maintaining cellular homoeostasis. This study aimed to elucidate the influence of TXNIP on the autophagy of β-cell. In this study, C57BL/6 mice and TXNIP

Indexed as

Insulin-Secreting CellsIslets of LangerhansAnimalsAutophagyCarrier ProteinsMiceMice, Inbred C57BLThioredoxinsCarrier ProteinsThioredoxinsTxnip protein, mouseAutophagyHigh-fat and high-sugar dietIslet β-cell dysfunctionThioredoxin-interacting protein

Identifiers

PMID32892310
OpenAlexW3083417211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.