Evidence map›Paper›PMID 32892291›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2022

Missed diagnoses and misdiagnoses of adults with autism spectrum disorder.

Laura Fusar-Poli, Natascia Brondino, Pierluigi Politi, Eugenio Aguglia

Open access · hybridAbstract read
In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 2 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 2 syntheses or guidelines pooled it, 187 citations in OpenAlex.

  1. The Association Between Maternal Asthma and Child Autism: A Systematic Review and Meta-Analysis.Autism research : official journal of the International Society for Autism Research · 2025
    Pooled it
  2. Pooled it
  3. Article
  4. [From clinical high risk for psychosis to autism spectrum disorder: navigating the challenges of differential diagnosis-A case report].Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026
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  12. Sex-specific metrics for success: Gaps in social word use are bigger for autistic girls than boys.Autism : the international journal of research and practice · 2026
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  15. Self-directed speech and attention deficit hyperactive disorder-like behaviours.British journal of psychology (London, England : 1953) · 2026
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  18. Forensic neuroimaging in childhood abduction, rape and murder case and trial outcome.Psychiatry, psychology, and law : an interdisciplinary journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law · 2026
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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Laura Fusar-PoliDepartment of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, via Santa Sofia 78, 95123, Catania, Italy. laura.fusarpoli@studium.unict.it.ORCID http://orcid.org/0000-0002-5847-6947
Natascia BrondinoDepartment of Brain and Behavioral Sciences, University of Pavia, via Bassi 21, 27100, Pavia, Italy.ORCID http://orcid.org/0000-0002-3128-1592
Pierluigi PolitiDepartment of Brain and Behavioral Sciences, University of Pavia, via Bassi 21, 27100, Pavia, Italy.ORCID http://orcid.org/0000-0002-4602-2032
Eugenio AgugliaDepartment of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, via Santa Sofia 78, 95123, Catania, Italy.ORCID http://orcid.org/0000-0003-2146-7737
University of Catania · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a group of life-long neurodevelopmental disorders affecting 1.5% of the general population. The present study aimed to evaluate the psychiatric history of a group of adults who received the first diagnosis of ASD in two Italian university centers. Diagnoses of ASD were confirmed by a team of psychiatrists with wide expertise in the field, after the administration of standardized tools (i.e., ADOS-2, ADI-R). The sample comprised 161 participants, of which 114 (79.5%) were males. The median age of diagnosis was 23 years (range 18-55), with a median IQ of 100 (range 30-145). The first evaluation by a mental health professional was performed at a median age of 13 years, with a gap of 11 years between the first evaluation and the diagnosis of ASD. 33.5% of participants had never received a psychiatric diagnosis, while the rest of the sample had received one or more diagnoses different from ASD. The most common past diagnoses were intellectual disability, psychoses, personality disorders, and depression. Sex differences were detected in the age of diagnosis and ADOS-2 scores. Our results provide important information for both child and adult psychiatrists. Given the prevalence of autism and the high rates of co-occurrent psychiatric conditions, it is important for clinicians to consider ASD in the differential diagnostic process.

Indexed as

Autism Spectrum DisorderMissed DiagnosisAdolescentAdultFemaleHumansMaleMiddle AgedYoung AdultAdultsAutism spectrum disorderDiagnosisFemale phenotypePsychiatrySex

Identifiers

PMID32892291
PMCPMC8866369
OpenAlexW3083547431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.