Evidence map›Paper›PMID 32892233›Full record

ArticleExperimental brain research2020

Protection of MCC950 against Alzheimer's disease via inhibiting neuronal pyroptosis in SAMP8 mice.

Jie Li, Lili Zhuang, Xiaoqing Luo, Jianheng Liang, Erwei Sun, Yi He

Abstract read
PubMed Publisher
In one paragraph

Article in Experimental brain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 64 citations in OpenAlex.

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  14. The role of NLRP3 inflammasome-mediated pyroptosis in astrocytes during hyperoxia-induced brain injury.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Jie LiDepartment of Neurology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Lili ZhuangDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Xiaoqing LuoDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Jianheng LiangDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Erwei SunDepartment of Rheumatology and Immunology, Shunde Hospital, Southern Medical University, Foshan, China. sunew@smu.edu.cn.
Yi HeDepartment of Rheumatology and Immunology, Shunde Hospital, Southern Medical University, Foshan, China. heyi1983@smu.edu.cn.
Guangdong Academy of Sciences · CNKey Laboratory of Guangdong Province · CNThe First People's Hospital of Shunde · CNThird Affiliated Hospital of Southern Medical University · CN

Funding

Medical Scientific Research Foundation of Guangdong Province No. A2017296National Natural Science Foundation of China 81501417National Natural Science Foundation of China 81671623National Natural Science Foundation of China 81873880
6 · The paper itself

Abstract

Neuronal dysfunction and loss are thought to be one of the causes of cognitive impairment in Alzheimer's disease (AD), but the specific mechanism of neuronal loss in the pathogenesis of AD remains controversial. This study explored the role of NLRP3 inflammasome-induced neuronal pyroptosis in neuronal loss of AD, and pioneered the use of NLRP3 inhibitor MCC950 to intervene in the treatment of senescence-accelerated mouse prone 8 (SAMP8) mice. In vitro, human primary neurons (HPNs) pretreated with MCC950 were stimulated with amyloid-β

Indexed as

Alzheimer DiseaseAnimalsDisease Models, AnimalFuransHeterocyclic Compounds, 4 or More RingsIndenesMiceNeuronsPyroptosisSulfonamidesSulfonesFuransHeterocyclic Compounds, 4 or More RingsIndenesN-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamideSulfonamidesSulfonesAlzheimer's diseaseMCC950Neuronal pyroptosisNLRP3 inflammasomeSAMP8 mice

Identifiers

PMID32892233
OpenAlexW3083109472

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.