Evidence map›Paper›PMID 32892219›Full record

ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2021

Acute kidney injury in renal transplant recipients undergoing cardiac surgery.

Gregory L Hundemer, Anand Srivastava, Kirolos A Jacob, Neeraja Krishnasamudram, Salman Ahmed, Emily Boerger, Shreyak Sharma, Kapil K Pokharel, Sameer A Hirji, Marc Pelletier and 5 more

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In one paragraph

Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Predictors and Adverse Outcomes of Acute Kidney Injury in Hospitalized Renal Transplant Recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Gregory L HundemerDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Anand SrivastavaDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Kirolos A JacobDepartment of Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
Neeraja KrishnasamudramDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Salman AhmedDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Emily BoergerDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Shreyak SharmaDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Kapil K PokharelDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sameer A HirjiDivision of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Marc PelletierDivision of Cardiac Surgery, University Hospitals, Case Western Reserve University, Cleveland, OH, USA.
Kassem SafaTransplant Center and Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Win KulvichitDepartment of Critical Care Medicine, Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, PA, USA.
John A KellumDepartment of Critical Care Medicine, Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, PA, USA.
Leonardo V RiellaDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
David E LeafDivision of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Harvard University · USBrigham and Women's Hospital · USUniversity of Pittsburgh · USCase Western Reserve University · USNorthwestern University · USOttawa Hospital · CAUniversity Medical Center Utrecht · NL

Funding

Non-Invasive Imaging Biomarkers to Identify a High-Risk Chronic Kidney Disease PhenotypeK23DK120811 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SRIVASTAVA, ANAND · 2020 to 2024
$1.0M
Dysregulated Mineral Metabolism and Acute Kidney InjuryK23DK106448 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI LEAF, DAVID EVAN · 2015 to 2019
$964k
NIDDK NIH HHS K23 DK106448NIDDK NIH HHS K23 DK120811
6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) is a key risk factor for chronic kidney disease in the general population, but has not been investigated in detail among renal transplant recipients (RTRs). We investigated the incidence, severity and risk factors for AKI following cardiac surgery among RTRs compared with non-RTRs with otherwise similar clinical characteristics.

methodsWe conducted a retrospective cohort study of RTRs (n = 83) and non-RTRs (n = 83) who underwent cardiac surgery at two major academic medical centers. Non-RTRs were matched 1:1 to RTRs by age, preoperative (preop) estimated glomerular filtration rate and type of cardiac surgery. We defined AKI according to Kidney Disease: Improving Global Outcomes criteria.

resultsRTRs had a higher rate of AKI following cardiac surgery compared with non-RTRs [46% versus 28%; adjusted odds ratio 2.77 (95% confidence interval 1.36-5.64)]. Among RTRs, deceased donor (DD) versus living donor (LD) status, as well as higher versus lower preop calcineurin inhibitor (CNI) trough levels, were associated with higher rates of AKI (57% versus 33% among DD-RTRs versus LD-RTRs; P = 0.047; 73% versus 36% among RTRs with higher versus lower CNI trough levels, P = 0.02). The combination of both risk factors (DD status and higher CNI trough level) had an additive effect (88% AKI incidence among patients with both risk factors versus 25% incidence among RTRs with neither risk factor, P = 0.004).

conclusionsRTRs have a higher risk of AKI following cardiac surgery compared with non-RTRs with otherwise similar characteristics. Among RTRs, DD-RTRs and those with higher preop CNI trough levels are at the highest risk.

Indexed as

Acute Kidney InjuryAgedCardiac Surgical ProceduresFemaleGlomerular Filtration RateHumansIncidenceKidney TransplantationMaleMiddle AgedRenal Insufficiency, ChronicRetrospective StudiesRisk FactorsTransplant RecipientsUnited Statesacute kidney injurycalcineurin inhibitorcardiac surgerykidney transplantrenal transplant

Identifiers

PMID32892219
PMCPMC7771983
OpenAlexW3083527840

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.