ArticleEnvironment international2020
Dysregulated lipid and fatty acid metabolism link perfluoroalkyl substances exposure and impaired glucose metabolism in young adults.
Article in Environment international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 4 syntheses or guidelines pooled it, 169 citations in OpenAlex.
- A bibliometric and text-mining analysis of lipidomics and metabolomics in human disease.Frontiers in physiology · 2026Pooled it
- The relationship between PFAS exposure and dyslipidemia: an updated review, meta-analysis, and evaluation of bias.European journal of epidemiology · 2025Pooled it
- Associations between Per- and Polyfluoroalkyl Substances Exposures and Blood Lipid Levels among Adults-A Meta-Analysis.Environmental health perspectives · 2023Pooled it
- Metabolic Signatures of Youth Exposure to Mixtures of Per- and Polyfluoroalkyl Substances: A Multi-Cohort Study.Environmental health perspectives · 2023Pooled it
- Respiratory Effects of Traffic-Related Air Pollution: A Randomized, Crossover Analysis of Lung Function, Airway Metabolome, and Biomarkers of Airway Injury.Environmental health perspectives · 2023Trial
- Per- and polyfluoroalkyl substances, perceived stress, and miscarriage risk in a cohort of US Black women.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Transcriptomic Perturbations in Placental Gene Expression Following Developmental Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide-Dimer Acid (HFPO-DA or GenX) in CD‑1 Mice Are Consistent with Placental Insufficiency.Environment & health (Washington, D.C.) · 2026Article
- Metabolome-wide association study identifies metabolites associated with human exposure to perfluoroalkyl substances.Journal of exposure science & environmental epidemiology · 2026Article
- PFAS and cardiovascular risk : The effects of exposure to perfluoroalkyl and polyfluoroalkyl substances on cardiovascular health.Wiener klinische Wochenschrift · 2026Review
- Combined Effects of PFAS and Metals on Cognitive Function.Environments (Basel, Switzerland) · 2026Article
- Recent advances and challenges of analytical methods for detection of perfluoroalkyl and polyfluoroalkyl substances.RSC advances · 2026Review
- Forever Chemicals, Finite Defenses: PFAS Burden the Liver, Break Mitochondria, and Outpace Modern Regulation.International journal of molecular sciences · 2026Review
- Per- and polyfluoroalkyl substances: A novel risk factor for cardiovascular disease.Ecotoxicology and environmental safety · 2026Review
- PFOA induced metabolic and immune perturbations in a SARS-2 infection model.bioRxiv : the preprint server for biology · 2026Article
- Per- and polyfluoroalkyl substances mixture exposure is associated with colorectal cancer TNM stage.Frontiers in toxicology · 2026Article
- Per- and Polyfluoroalkyl Substances, Serum Lipidome, and Clinical Outcomes after Percutaneous Coronary Intervention in Type 2 Diabetic Patients: A Prospective Nested Case-control Study.Journal of atherosclerosis and thrombosis · 2025Article
- Environmental behavior and human health risks of PFAS: occurrence, toxicity, and the state-of-the-art removal approaches.RSC advances · 2025Review
- Synergistic toxicity in alcohol-associated liver disease and PFAS exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2025Review
- Review
- Exposure to per- and poly-fluoroalkyl substances in association to later occurrence of type 2 diabetes and metabolic pathway dysregulation in a multiethnic US population.EBioMedicine · 2025Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundPer- and polyfluoroalkyl substances (PFASs) exposure is ubiquitous among the US population and has been linked to adverse health outcomes including cardiometabolic diseases, immune dysregulation and endocrine disruption. However, the metabolic mechanism underlying the adverse health effect of PFASs exposure is unknown.
objectiveThe aim of this project is to investigate the association between PFASs exposure and altered metabolic pathways linked to increased cardiometabolic risk in young adults.
methodsA total of 102 young adults with 82% overweight or obese participants were enrolled from Southern California between 2014 and 2017. Cardiometabolic outcomes were assessed including oral glucose tolerance test (OGTT) measures, body fat and lipid profiles. High-resolution metabolomics was used to quantify plasma exposure levels of three PFAS congeners and intensity profiles of the untargeted metabolome. Fasting concentrations of 45 targeted metabolites involved in fatty acid and lipid metabolism were used to verify untargeted metabolomics findings. Bayesian Kernel Machine Regression (BKMR) was used to examine the associations between PFAS exposure mixture and cardiometabolic outcomes adjusting for covariates. Mummichog pathway enrichment analysis was used to explore PFAS-associated metabolic pathways. Moreover, the effect of PFAS exposure on the metabolic network, including metabolomic profiles and cardiometabolic outcomes, was investigated.
resultsHigher exposure to perfluorooctanoic acid (PFOA) was associated with higher 30-minute glucose levels and glucose area under the curve (AUC) during the OGTT (p < 0.001). PFAS exposure was also associated with altered lipid pathways, which contributed to the metabolic network connecting PFOA and higher glucose levels following the OGTT. Targeted metabolomics analysis indicated that higher PFOA exposure was associated with higher levels of glycerol (p = 0.006), which itself was associated with higher 30-minute glucose (p = 0.006).
conclusionsIncreased lipolysis and fatty acid oxidation could contribute to the biological mechanisms linking PFAS exposure and impaired glucose metabolism among young adults. Findings of this study warrants future experimental studies and epidemiological studies with larger sample size to replicate.
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