Evidence map›Paper›PMID 32891958›Full record

ReviewCurrent opinion in virology2021

Measles immunity and immunosuppression.

Diane E Griffin

Open access · hybridAbstract readReview
In one paragraph

Review in Current opinion in virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Comprehensive mapping of human CD4Cell reports. Medicine · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Measles virus reprograms CD4Frontiers in cell and developmental biology · 2026
    Article
  12. Caspase-8 expression in CD8Science advances · 2025
    Article
  13. Article
  14. Review
  15. Congenital measles: A rare but life-threatening consequence of Canada's largest measles outbreak.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2025
    Article
  16. Article
  17. Article
  18. Secondary Immunodeficiency.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2025
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Diane E GriffinW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. Electronic address: dgriffi6@jhu.edu.
Johns Hopkins University · US

Funding

Physiological and immunological responses to measles vaccineR01AI131228 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GRIFFIN, DIANE E · 2018 to 2021
$2.7M
Vitamin A-Mediated Protection in MeaslesR21AI095981 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GRIFFIN, DIANE E · 2013 to 2014
$446k
NIAID NIH HHS R01 AI131228NIAID NIH HHS R21 AI095981
6 · The paper itself

Abstract

Effects of measles on the immune system are only partially understood. Lymphoid tissue is a primary site of measles virus (MeV) replication where CD150 is the receptor for infection of both B and T cells. Lymphocyte depletion occurs during the acute phase of infection, but initiation of the adaptive immune response leads to extensive lymphocyte proliferation, production of MeV-specific antibody and T cells, the rash and clearance of infectious virus. Viral RNA persists in lymphoid tissue accompanied by ongoing germinal center proliferation, production of antibody-secreting cells, functionally distinct populations of T cells and antibody avidity maturation to establish life-long immunity. However, at the same time diversity of pre-existing antibodies and numbers of memory and naive B cells are reduced and susceptibility to other infections is increased.

Indexed as

Immune ToleranceAdaptive ImmunityAntibodies, ViralHumansImmunity, CellularLymphoid TissueMeaslesMeasles virusVirus ReplicationAntibodies, Viral

Identifiers

PMID32891958
PMCPMC7994291
OpenAlexW3083513837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.