Trial reportNeuroImage. Clinical2020
A multicenter effectiveness trial of QEEG-informed neurofeedback in ADHD: Replication and treatment prediction.
Trial report in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05635318 (Quantitative EEG Neurofeedback as an Add-on Therapy For Attention-deficit Hyperactivity Disorder), which is not on this map. Cited by 23 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Quantitative EEG Neurofeedback as an Add-on Therapy For Attention-deficit Hyperactivity Disorder (ADHD)
Who cites it
23 citing papers in PubMed, 5 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Challenging the Diagnostic Value of Theta/Beta Ratio: Insights From an EEG Subtyping Meta-Analytical Approach in ADHD.Applied psychophysiology and biofeedback · 2025Pooled it
- Challenging the Diagnostic Value of Theta/Beta Ratio: Insights From an EEG Subtyping Meta-Analytical Approach in ADHD.Applied psychophysiology and biofeedback · 2025Pooled it
- Comparative Efficacy of Neurofeedback Interventions for Attention-Deficit/Hyperactivity Disorder in Children: A Network Meta-Analysis.Brain and behavior · 2024Pooled it
- Proposing a "Brain Health Checkup (BHC)" as a Global Potential "Standard of Care" to Overcome Reward Dysregulation in Primary Care Medicine: Coupling Genetic Risk Testing and Induction of "Dopamine Homeostasis".International journal of environmental research and public health · 2022Pooled it
- How standardized are "standard protocols"? Variations in protocol and performance evaluation for slow cortical potential neurofeedback: A systematic review.Frontiers in human neuroscience · 2022Pooled it
- Theta/Beta Ratio Neurofeedback Effects on Resting and Task-Related Theta Activity in Children with ADHD.Applied psychophysiology and biofeedback · 2025Trial
- Stratification of responses to tDCS intervention in a healthy pediatric population based on resting-state EEG profiles.Scientific reports · 2023Trial
- The neural and physiological mechanisms of Animal-Assisted Interventions (AAI): A systematic review and integrated framework.Comprehensive psychoneuroendocrinology · 2026Review
- Theta beta ratio in attention deficit hyperactivity disorder using a multiverse analysis.eLife · 2026Article
- EEG Neurofeedback for Major Depressive Disorder: A Scoping Review.Alpha psychiatry · 2026Review
- An explainable machine learning-based approach to predicting treatment response for neurofeedback in ADHD.Scientific reports · 2025Article
- Effects of a novel non-pharmacological intervention based on respiratory biofeedback, neurofeedback and median nerve stimulation to treat children with ADHD.Frontiers in human neuroscience · 2025Article
- Translating Decades of Neuroscience Research into Diagnostic and Treatment Biomarkers for ADHD.Advances in neurobiology · 2024Review
- Treatment biomarkers for ADHD: Taking stock and moving forward.Translational psychiatry · 2022Review
- Neurofeedback for the Education of Children with ADHD and Specific Learning Disorders: A Review.Brain sciences · 2022Review
- Neurological Mechanisms of Diagnosis and Therapy in School Children with ADHD in Poland.International journal of environmental research and public health · 2022Article
- The two decades brainclinics research archive for insights in neurophysiology (TDBRAIN) database.Scientific data · 2022Article
- Self-management training vs. neurofeedback interventions for attention deficit hyperactivity disorder: Results of a randomized controlled treatment study.Frontiers in psychiatry · 2022Article
- Editorial: Clinical Neurofeedback.NeuroImage. Clinical · 2022Article
- Changes in EEG Recordings in COVID-19 Patients as a Basis for More Accurate QEEG Diagnostics and EEG Neurofeedback Therapy: A Systematic Review.Journal of clinical medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionQuantitative Electroencephalogram-(QEEG-)informed neurofeedback is a method in which standard neurofeedback protocols are assigned, based on individual EEG characteristics in order to enhance effectiveness. Thus far clinical effectiveness data have only been published in a small sample of 21 ADHD patients. Therefore, this manuscript aims to replicate this effectiveness in a new sample of 114 patients treated with QEEG-informed neurofeedback, from a large multicentric dataset and to investigate potential predictors of neurofeedback response.
methodsA sample of 114 patients were included as a replication sample. Patients were treated with standard neurofeedback protocols (Sensori-Motor-Rhythm (SMR), Theta-Beta (TBR), or Slow Cortical Potential (SCP) neurofeedback), in combination with coaching and sleep hygiene advice. The ADHD Rating Scale (ADHD-RS) and Pittsburgh Sleep Quality Index (PSQI) were assessed at baseline, every 10th session, and at outtake. Holland Sleep Disorder Questionnaire (HSDQ) was assessed at baseline and outtake. Response was defined as ≥25% reduction (R25), ≥50% reduction (R50), and remission. Predictive analyses were focused on predicting remission status.
resultsIn the current sample, response rates were 85% (R25), 70% (R50), and remission was 55% and clinical effectiveness was not significantly different from the original 2012 sample. Non-remitters exhibited significantly higher baseline hyperactivity ratings. Women who remitted had significantly shorter P300 latencies and boys who remitted had significantly lower iAPF's. DISCUSSION: In the current sample, clinical effectiveness was replicated, suggesting it is possible to assign patients to a protocol based on their individual baseline QEEG to enhance signal-to-noise ratio. Furthermore, remitters had lower baseline hyperactivity scores. Likewise, female remitters had shorter P300 latencies, whereas boys who remitted have a lower iAPF. Our data suggests initial specificity in treatment allocation, yet further studies are needed to replicate the predictors of neurofeedback remission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.