Evidence map›Paper›PMID 32891531›Full record

ArticlePancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]2020

Class III obesity rather than metabolic syndrome impacts clinical outcomes of acute pancreatitis: A propensity score weighted analysis.

Alecia M Blaszczak, Somashekar G Krishna, Phil A Hart, David Bradley, Willa Hsueh, Luis F Lara, Hisham Hussan, Alice Hinton, Darwin L Conwell, Zobeida Cruz-Monserrate

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Observational
  5. Review
  6. Article
  7. Fatty liver disease and pancreatic inflammation-A lethal combination?United European gastroenterology journal · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Alecia M BlaszczakDiabetes and Metabolism Research Center, Division of Endocrinology, Diabetes & Metabolism, Department of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, 43210, USA.
Somashekar G KrishnaDivision of Gastroenterology, Hepatology, and Nutrition, Division of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, 43210, USA; The Comprehensive Cancer Center, Arthur G. James Cancer Hospital, Richard J. Solove Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Phil A HartDivision of Gastroenterology, Hepatology, and Nutrition, Division of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, 43210, USA; The Comprehensive Cancer Center, Arthur G. James Cancer Hospital, Richard J. Solove Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
David BradleyDiabetes and Metabolism Research Center, Division of Endocrinology, Diabetes & Metabolism, Department of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, 43210, USA.
Willa HsuehDiabetes and Metabolism Research Center, Division of Endocrinology, Diabetes & Metabolism, Department of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, 43210, USA.
Luis F LaraDivision of Gastroenterology, Hepatology, and Nutrition, Division of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, 43210, USA; The Comprehensive Cancer Center, Arthur G. James Cancer Hospital, Richard J. Solove Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Hisham HussanDivision of Gastroenterology, Hepatology, and Nutrition, Division of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, 43210, USA; The Comprehensive Cancer Center, Arthur G. James Cancer Hospital, Richard J. Solove Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Alice HintonDivision of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH, 43210, USA.
Darwin L ConwellDivision of Gastroenterology, Hepatology, and Nutrition, Division of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, 43210, USA; The Comprehensive Cancer Center, Arthur G. James Cancer Hospital, Richard J. Solove Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Zobeida Cruz-MonserrateDivision of Gastroenterology, Hepatology, and Nutrition, Division of Internal Medicine, The Ohio State University, Wexner Medical Center, Columbus, OH, 43210, USA; The Comprehensive Cancer Center, Arthur G. James Cancer Hospital, Richard J. Solove Research Institute, The Ohio State University, Columbus, OH, 43210, USA. Electronic address: zobeida.cruz-monserrate@osumc.edu.
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · USThe Ohio State University Wexner Medical Center · USThe Ohio State University · US

Funding

The Ohio State University Pancreatic Disorders Network (OSU-PDN)U01DK108327 · NIDDK · OHIO STATE UNIVERSITY · PI CONWELL, DARWIN LEWIS, HART, PHILIP A. · 2015 to 2024
$5.5M
Role of Lipocalin 2 in Pancreatic CancerR01CA223204 · NCI · OHIO STATE UNIVERSITY · PI CRUZ-MONSERRATE, ZOBEIDA · 2018 to 2022
$1.9M
NCI NIH HHS R01 CA223204NIDDK NIH HHS U01 DK108327
6 · The paper itself

Abstract

objectivesThe incidence rates of acute pancreatitis (AP) and the prevalence of class III obesity, and metabolic syndrome (MetS) are increasing in the US. Since class III obesity was associated with adverse clinical outcomes of AP, we sought to understand if the presence of metabolic comorbidities collectively recognized, as MetS were associated with worse clinical outcomes and increased health-care utilization.

methodsThe Nationwide Readmissions Database (NRD) (2010-2014) was reviewed to identify all adult subjects with a principal discharge diagnosis of AP. Inpatient mortality, severe AP (SAP), and 30-day readmissions were the primary outcomes analyzed. Propensity score weighted analyses were used to compare AP subjects with and without MetS and were further stratified by class III obesity status.

resultsMetS was associated with 12.91% (139,165/1,078,183) of all admissions with AP. Propensity score weighted analyses showed that MetS was associated with an increased proportion of SAP (OR 1.21, 95% CI 1.17, 1.25), but decreased mortality (OR 0.62, 95% CI 0.54, 0.70) and 30-day readmissions (OR 0.86, 95% CI 0.83, 0.89). Propensity score weighted analyses also revealed that class III obesity was independently associated with increased mortality in AP subjects with (OR 1.92, 95% CI 1.41, 2.61) and without MetS (OR 1.55, 95% CI 1.26, 1.92), and increased SAP in subjects with and without MetS.

conclusionsClass III obesity appears to be the primary factor associated with adverse clinical outcomes in subjects with MetS admitted with AP. This has significant implications for patient management and future research targeting AP.

Indexed as

Acute DiseaseAdultAgedAged, 80 and overBody Mass IndexComorbidityDatabases, FactualFemaleHospital CostsHospital MortalityHumansMaleMetabolic SyndromeMiddle AgedObesity, MorbidPancreatitisAcute pancreatitisBody mass indexClass III obesityMetabolic syndromeNationwide readmissions databaseObesity

Identifiers

PMID32891531
PMCPMC7780090
OpenAlexW3080707860

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.