Evidence map›Paper›PMID 32891428›Full record

ArticleTrends in pharmacological sciences2020

Amphiphilic Polyacrylamide Excipients Lead to a Record-Breaking Fast-Acting Insulin.

Pavimol Angsantikul, Samir Mitragotri

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in pharmacological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The 'What, Why, Where and How' of Delivering a Drug.Trends in pharmacological sciences · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Pavimol AngsantikulSchool of Engineering and Applied Sciences and Wyss Institute, Harvard University, 29 Oxford Street, Cambridge, MA 02138, USA.
Samir MitragotriSchool of Engineering and Applied Sciences and Wyss Institute, Harvard University, 29 Oxford Street, Cambridge, MA 02138, USA. Electronic address: mitragotri@seas.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fast-acting insulins are central to the regulation of prandial glucose in diabetic patients. Current fast-acting insulins require 20-30 min for the onset and longer for the peak blood concentrations. The recent work by Mann et al. used high-throughput synthesis and screening of polyacrylamide-based excipients to yield a formulation with pharmacokinetics that is faster than the currently available fast-acting insulins.

Indexed as

ExcipientsInsulinAcrylic ResinsHumansHypoglycemic AgentsPolyacrylamidesAcrylic ResinsExcipientsHypoglycemic AgentsInsulinPolyacrylamidescopolymerdiabetesfast actinginsulin analogpostprandial glucosesubcutaneous

Identifiers

PMID32891428

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.