Evidence map›Paper›PMID 32891139›Full record

Trial reportBMC pediatrics2020

Vitamin D supplementation in obese Sri Lankan children: a randomized controlled trial.

D B D L Samaranayake, S G S Adikaram, N Atapattu, K M D L D Kendaragama, J T N Senevirathne, H D Jayasekera, V P Wickramasinghe

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

D B D L SamaranayakeDepartment of Community Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
S G S AdikaramColombo South Teaching Hospital, Kalubowila, Sri Lanka.
N AtapattuLady Ridgeway Hospital, Colombo, Sri Lanka.
K M D L D KendaragamaLady Ridgeway Hospital, Colombo, Sri Lanka.
J T N SenevirathneDepartment of Paediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
H D JayasekeraDepartment of Paediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
V P WickramasingheDepartment of Paediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. pujithaw@yahoo.com.ORCID 0000-0002-8355-1283
University of Colombo · LKLady Ridgeway Hospital for Children · LKColombo North Teaching Hospital · LK

Funding

National Science Foundation RG/2015/HS/09
6 · The paper itself

Abstract

backgroundMicronutrient deficiencies are identified among obese individuals. Vitamin D deficiency (VDD) is prevalent in obese children, and is hypothesized to cause insulin resistance and metabolic abnormalities. This study aimed to determine the effect of vitamin D supplementation on obesity and related metabolic abnormalities among obese Sri Lankan children with VDD.

methodsA triple-blind randomized controlled trial was conducted among vitamin D deficient (< 20 ng/ml), obese children (n = 96), randomly allocated to three intervention arms - treatment arm receiving weekly vitamin D

resultsWaist circumference Z-score, %FM and serum calcium significantly improved across all three arms, ALT significantly improved in treatment and supplementation arms while, BMI Z-score, PTH and vitamin D significantly improved in the treatment arm. Biceps (p = 0.035) and subscapular (0.048) skin fold thickness, vitamin D (p = 0.004) and ALT (p = 0.012) significantly improved in the treatment arm.

conclusionsA strict dietary and physical activity regimen could improve some of the anthropometric, body composition and metabolic profiles, but high dose vitamin D, enhances those improvements. Therefore high dose vitamin D seems to potentiate management outcomes of obese children with vitamin D deficiency.

trial registrationThe study was registered at the Sri Lanka Clinical Trials Registry (SLCTR/2015/017) on 12th September 2015 at https://slctr.lk/trials/slctr-2015-017 .

Indexed as

Dietary SupplementsVitamin D DeficiencyBlood GlucoseChildDouble-Blind MethodHumansObesitySri LankaVitamin DBlood GlucoseVitamin DChildhood obesityInsulin resistanceRandomized controlled trialSri LankaVitamin D deficiency

Identifiers

PMID32891139
PMCPMC7487456
OpenAlexW3083197493

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.