ReviewJournal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)2020
Environmental influence on neurodevelopmental disorders: Potential association of heavy metal exposure and autism.
Review in Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression.Journal of autism and developmental disorders · 2022Pooled it
- Early exposure to agricultural pesticides and the occurrence of autism spectrum disorder: a systematic review.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2022Pooled it
- Genetic mutations and synaptic dysfunctions in social interaction disorders: insights from invertebrate models to humans.Metabolic brain disease · 2026Review
- The Genetic Exploration of the Association Between Heavy Metal Exposure in Environmental Pollution and Multi-system Diseases.Biological trace element research · 2026Article
- Elemental and Isotopic Profiles in Blood and Urine of Jordanian Children with Autism Spectrum Disorder: a Preliminary Comparative Study with Neurotypical Children.Biological trace element research · 2026Article
- Environmental metal exposure and autism spectrum disorder: spatial analysis of exposure patterns and associated risk among children in Alabama.Environmental science and pollution research international · 2026Article
- Associations of prenatal fine particulate matter mixtures with neurodevelopmental outcomes in early childhood: component- and source-specific insights.Particle and fibre toxicology · 2026Article
- Evaluation of Heavy Metals and Essential Minerals in the Hair of Children with Autism Spectrum Disorder and Their Association with Symptom Severity.Biological trace element research · 2025Article
- Associations between element mixtures and biomarkers of pathophysiologic pathways related to autism spectrum disorder.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2025Article
- An Integrative Approach to Identifying Neuroprotective Natural Compounds for Neurodevelopmental Disorders.International journal of molecular sciences · 2025Article
- Exploring pathological targets and advancing pharmacotherapy in autism spectrum disorder: Contributions of glial cells and heavy metals.Histology and histopathology · 2025Review
- Maternal choline supplementation in neurodevelopmental disorders: mechanistic insights from animal models and future directions.Nutritional neuroscience · 2025Review
- Associations of prenatal metal exposure with child neurodevelopment and mediation by perturbation of metabolic pathways.Nature communications · 2025Article
- Unveiling complex patterns: An information-theoretic approach to high-order behaviors in microarray data.PloS one · 2025Article
- Heavy Metal Contamination: Sources, Health Impacts, and Sustainable Mitigation Strategies with Insights from Nigerian Case Studies.F1000Research · 2025Review
- Perturbed synaptic adhesion molecules signaling in neurodevelopmental disorders: The impact of metal neurotoxicity.Ibrain · 2025Review
- Observational methods for human studies of transgenerational effects.Epigenetics · 2024Article
- Prenatal environmental risk factors for autism spectrum disorder and their potential mechanisms.BMC medicine · 2024Review
- Genetic and Environmental Factors Co-Contributing to Behavioral Abnormalities inInternational journal of molecular sciences · 2024Article
- Prenatal Nutritional Factors and Neurodevelopmental Disorders: A Narrative Review.Life (Basel, Switzerland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
Environmental factors have been severally established to play major roles in the pathogenesis of neurodevelopmental disorders including autism spectrum disorder (ASD). ASD is a neurodevelopmental disorder that is associated with symptoms that reduce the quality of life of affected individuals such as social interaction deficit, cognitive impairment, intellectual disabilities, restricted and repetitive behavioural patterns. ASD pathogenesis has been associated with environmental and genetic factors that alter physiologic processes during development. Here, we review literatures highlighting the environmental impact on neurodevelopmental disorders, and mechanisms by which environmental toxins may influence neurodevelopment. Furthermore, this review discusses reports highlighting neurotoxic metals (specifically, lead, mercury, cadmium, nickel and manganese) as environmental risk factors in the aetiology of ASD. This work, thus suggests that improving the environment could be vital in the management of ASD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.