ArticleDevelopmental cognitive neuroscience2020
Childhood violence exposure and social deprivation predict adolescent amygdala-orbitofrontal cortex white matter connectivity.
Article in Developmental cognitive neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Childhood Material Hardship Linked to Adolescent Neurocognition: A Computational Modeling Approach.Developmental science · 2026Article
- Childhood adversity and adolescent mental health: Examining cumulative and specificity effects across contexts and developmental timing.Development and psychopathology · 2025Article
- Human amygdala nuclei show distinct developmental trajectories from adolescence to adulthood in functional integration with prefrontal circuitry.Cell reports · 2025Article
- What's the harm? Examining police contact and amygdala reactivity among black adolescents.Social cognitive and affective neuroscience · 2025Article
- The Promise and Challenges of Integrating Biological and Prevention Sciences: A Community-Engaged Model for the Next Generation of Translational Research.Prevention science : the official journal of the Society for Prevention Research · 2024Article
- Mother-child closeness and adolescent structural neural networks: a prospective longitudinal study of low-income families.Social cognitive and affective neuroscience · 2024Article
- Introducing the Neuroplastic Narrative: a non-pathologizing biological foundation for trauma-informed and adverse childhood experience aware approaches.Frontiers in psychiatry · 2023Article
- Amygdala reactivity during socioemotional processing and cortisol reactivity to a psychosocial stressor.Psychoneuroendocrinology · 2022Article
- Differential Developmental Associations of Material Hardship Exposure and Adolescent Amygdala-Prefrontal Cortex White Matter Connectivity.Journal of cognitive neuroscience · 2022Article
- Adolescent social isolation induces distinct changes in the medial and lateral OFC-BLA synapse and social and emotional alterations in adult mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Deadly gun violence, neighborhood collective efficacy, and adolescent neurobehavioral outcomes.PNAS nexus · 2022Article
- The effects of early life adversity on children's mental health and cognitive functioning.Translational psychiatry · 2022Review
- Early life stress is associated with the default mode and fronto-limbic network connectivity among young adults.Frontiers in behavioral neuroscience · 2022Article
- Contributions of the Fragile Families and Child Wellbeing Study to Child Development.Annual review of developmental psychology · 2021Article
- Association of Childhood Violence Exposure With Adolescent Neural Network Density.JAMA network open · 2020Observational
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9 authors.
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Abstract
Childhood adversity is heterogeneous with potentially distinct dimensions of violence exposure and social deprivation. These dimensions may differentially shape emotion-based neural circuitry, such as amygdala-PFC white matter connectivity. Amygdala-orbitofrontal cortex (OFC) white matter connectivity has been linked to regulation of the amygdala's response to emotional stimuli. Using a preregistered analysis plan, we prospectively examined the effects of childhood exposure to two dimensions of adversity, violence exposure and social deprivation, on the adolescent amygdala-PFC white matter connectivity. We also reproduced the negative correlation between amygdala-PFC white matter connectivity and amygdala activation to threat faces. 183 15-17-year-olds were recruited from the Fragile Families and Child Wellbeing Study - a longitudinal, birth cohort, sample of predominantly low-income youth. Probabilistic tractography revealed that childhood violence exposure and social deprivation interacted to predict the probability of adolescent right hemisphere amygdala-OFC white matter connectivity. High violence exposure with high social deprivation related to less amygdala-OFC white matter connectivity. Violence exposure was not associated with white matter connectivity when social deprivation was at mean or low levels (i.e., relatively socially supportive contexts). Therefore, social deprivation may exacerbate the effects of childhood violence exposure on the development of white matter connections involved in emotion processing and regulation. Conversely, social support may buffer against them.
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