Evidence map›Paper›PMID 32889654›Full record

ArticleMolecular neurobiology2021

Characterization of Anchorless Human PrP With Q227X Stop Mutation Linked to Gerstmann-Sträussler-Scheinker Syndrome In Vivo and In Vitro.

Pingping Shen, Johnny Dang, Zerui Wang, Weiguanliu Zhang, Jue Yuan, Yue Lang, Mingxuan Ding, Marcus Mitchell, Qingzhong Kong, Jiachun Feng and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Post-translational modifications in prion diseases.Frontiers in molecular neuroscience · 2024
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Pingping ShenDepartment of Neurology, First Hospital of Jilin University, Changchun, Jilin Province, People's Republic of China.
Johnny DangDepartments of Pathology and Neurology, Case Western Reserve University School of Medicine, 2085 Adelbert Road, Cleveland, OH, USA.
Zerui WangDepartment of Neurology, First Hospital of Jilin University, Changchun, Jilin Province, People's Republic of China.
Weiguanliu ZhangDepartment of Neurology, First Hospital of Jilin University, Changchun, Jilin Province, People's Republic of China.
Jue YuanDepartments of Pathology and Neurology, Case Western Reserve University School of Medicine, 2085 Adelbert Road, Cleveland, OH, USA.
Yue LangDepartment of Neurology, First Hospital of Jilin University, Changchun, Jilin Province, People's Republic of China.
Mingxuan DingDepartment of Neurology, First Hospital of Jilin University, Changchun, Jilin Province, People's Republic of China.
Marcus MitchellDepartments of Pathology and Neurology, Case Western Reserve University School of Medicine, 2085 Adelbert Road, Cleveland, OH, USA.
Qingzhong KongDepartments of Pathology and Neurology, Case Western Reserve University School of Medicine, 2085 Adelbert Road, Cleveland, OH, USA.
Jiachun FengDepartment of Neurology, First Hospital of Jilin University, Changchun, Jilin Province, People's Republic of China.
Annemiek J M RozemullerDutch Surveillance Center for Prion Diseases, University Medical Center Utrecht, Utrecht, The Netherlands. JM.Rozemuller@vumc.nl.
Li CuiDepartment of Neurology, First Hospital of Jilin University, Changchun, Jilin Province, People's Republic of China. chuili1967@126.com.
Robert B PetersenDepartments of Pathology and Neurology, Case Western Reserve University School of Medicine, 2085 Adelbert Road, Cleveland, OH, USA. robert.petersen@cmich.edu.
Wen-Quan ZouDepartments of Pathology and Neurology, Case Western Reserve University School of Medicine, 2085 Adelbert Road, Cleveland, OH, USA. wxz6@case.edu.ORCID http://orcid.org/0000-0001-8062-0370
Jilin University · CNUniversity School · USCentral Michigan University · USUniversity Medical Center Utrecht · NL

Funding

Role of skin prions in disease transmission and diagnostic testing of human prion diseaseR01NS109532 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI KONG, QINGZHONG · 2018 to 2022
$2.9M
Cervid to human prion transmissionR01NS088604 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI KONG, QINGZHONG · 2015 to 2018
$1.4M
NINDS NIH HHS R01 NS088604NINDS NIH HHS R01 NS109532
6 · The paper itself

Abstract

Alteration in cellular prion protein (PrP

Indexed as

AdultAnimalsAntibodiesAutopsyBrainCell Line, TumorCell MembraneCentrifugation, Density GradientCodon, NonsenseFemaleGerstmann-Straussler-Scheinker DiseaseGlycosylationHumansMice, TransgenicPrionsProtein AggregatesAntibodiesCodon, NonsensePrionsProtein AggregatesAllelic originGerstmann-Sträussler-Scheinker (GSS) syndromeGlycosylphosphatidylinositol (GPI) anchorMutationPrion diseasePrion proteinPrionsProtein misfolding cyclic amplification (PMCA)

Identifiers

PMID32889654
PMCPMC7695670
OpenAlexW3083331015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.