Evidence map›Paper›PMID 32889615›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

Head-to-head comparison of DFO* and DFO chelators: selection of the best candidate for clinical

Marion Chomet, Maxime Schreurs, Maria J Bolijn, Mariska Verlaan, Wissam Beaino, Kari Brown, Alex J Poot, Albert D Windhorst, Herman Gill, Jan Marik and 6 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 78 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 3 countries.

Marion ChometRadiology & Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan, 1117, Amsterdam, The Netherlands.
Maxime SchreursRadiology & Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan, 1117, Amsterdam, The Netherlands.
Maria J BolijnRadiology & Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan, 1117, Amsterdam, The Netherlands.
Mariska VerlaanRadiology & Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan, 1117, Amsterdam, The Netherlands.
Wissam BeainoRadiology & Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan, 1117, Amsterdam, The Netherlands.
Kari BrownRadiology & Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan, 1117, Amsterdam, The Netherlands.
Alex J PootRadiology & Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan, 1117, Amsterdam, The Netherlands.
Albert D WindhorstRadiology & Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan, 1117, Amsterdam, The Netherlands.
Herman GillGenentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Jan MarikGenentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Simon WilliamsGenentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Joseph CowellInstitute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, Chimie ParisTech, PSL University, CNRS, Paris, France.
Gilles GasserInstitute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, Chimie ParisTech, PSL University, CNRS, Paris, France.
Thomas L MindtLudwig Boltzmann Institute for Applied Diagnostics, General Hospital Vienna (AKH), Vienna, Austria.
Guus A M S van DongenRadiology & Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan, 1117, Amsterdam, The Netherlands.
Danielle J VugtsRadiology & Nuclear Medicine, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan, 1117, Amsterdam, The Netherlands. d.vugts@amsterdamumc.nl.ORCID http://orcid.org/0000-0001-7068-8152
Amsterdam University Medical Centers · NLCentre National de la Recherche Scientifique · FRAmsterdam Neuroscience · NLLudwig Boltzmann Institute Applied Diagnostics · AT

Funding

H2020 Marie Skłodowska-Curie Actions 675417Swiss National Science Foundation SNSF 205321_157216
6 · The paper itself

Abstract

purposeAlmost all radiolabellings of antibodies with

methodsCetuximab, trastuzumab and B12 (non-binding control antibody) were labelled with

results[

conclusionDFO*-mAb conjugates provide lower bone uptake than their DFO analogues; thus, DFO* is a superior candidate for preclinical and clinical

Indexed as

Chelating AgentsRadioisotopesAnimalsCell Line, TumorDeferoxamineMicePositron-Emission TomographyTissue DistributionZirconiumChelating AgentsDeferoxamineRadioisotopesZirconium89Zr-immuno-PETBone metastasis modelDFODFO*DFO*SqDFOSq

Identifiers

PMID32889615
PMCPMC8036225
OpenAlexW3083221182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.