Evidence map›Paper›PMID 32889597›Full record

ReviewCurrent topics in microbiology and immunology2021

Human Gastrointestinal Organoid Models for Studying Microbial Disease and Cancer.

Jayati Chakrabarti, Martha B Dua-Awereh, Loryn Holokai, Yana Zavros

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current topics in microbiology and immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jayati ChakrabartiDepartment of Cellular and Molecular Medicine, University of Arizona College of Medicine-Tucson, 1333 N. Martin Avenue, LSN 412, Tucson, AZ 85719-0000, AZ, USA.
Martha B Dua-AwerehDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, MSB 4202, Cincinnati, OH 45267-0000, OH, USA.
Loryn HolokaiMerck Pharmaceuticals, San Francisco, CA, USA.
Yana ZavrosDepartment of Cellular and Molecular Medicine, University of Arizona College of Medicine-Tucson, 1333 N. Martin Avenue, LSN 412, Tucson, AZ 85719-0000, AZ, USA. yzavros@arizona.edu.

Funding

The role of Hedgehog Signaling in gastric tissue repair and regenerationR01DK083402 · NIDDK · UNIVERSITY OF CINCINNATI · PI ZAVROS, YANA · 2011 to 2019
$3.7M
NIDDK NIH HHS R01 DK083402
6 · The paper itself

Abstract

One of the major discoveries in stem cell research in the past decade embraces the development of "organs in a dish," also known as "organoids." Organoids are three-dimensional cellular structures derived from primary stem cells of different organ-specific cell types which are capable of self-renewal and maintenance of the parental lineages. Researchers have developed in vitro organoid models to mimic in vivo host-microbial interactions and disease. In this review, we focus on the use of gastrointestinal organoids as models of microbial disease and cancer.

Indexed as

NeoplasmsOrganoidsGastrointestinal TractHumans

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.