Evidence map›Paper›PMID 32889573›Full record

ArticleJournal of bone and mineral metabolism2021

Jabuticaba peel extract modulates adipocyte and osteoblast differentiation of MSCs from healthy and osteoporotic rats.

Alann Thaffarell Portilho Souza, Gileade Pereira Freitas, Helena Bacha Lopes, Gabriela Guaraldo Campos Totoli, Adriana Gadioli Tarone, Mario Roberto Marostica-Junior, Adalberto Luiz Rosa, Marcio Mateus Beloti

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In one paragraph

Article in Journal of bone and mineral metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Alann Thaffarell Portilho Souza *Bone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Av Do Café S/N, Ribeirão Preto, SP, 14040-904, Brazil.ORCID http://orcid.org/0000-0001-7344-5420
Gileade Pereira Freitas *Bone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Av Do Café S/N, Ribeirão Preto, SP, 14040-904, Brazil.ORCID http://orcid.org/0000-0002-1674-4667
Helena Bacha LopesBone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Av Do Café S/N, Ribeirão Preto, SP, 14040-904, Brazil.ORCID http://orcid.org/0000-0002-6998-5296
Gabriela Guaraldo Campos TotoliBone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Av Do Café S/N, Ribeirão Preto, SP, 14040-904, Brazil.ORCID http://orcid.org/0000-0002-4472-0291
Adriana Gadioli TaroneSchool of Food Engineering, University of Campinas, Rua Monteiro Lobato 80, Campinas, 13083-862, SP, Brazil.ORCID http://orcid.org/0000-0002-3812-6472
Mario Roberto Marostica-JuniorSchool of Food Engineering, University of Campinas, Rua Monteiro Lobato 80, Campinas, 13083-862, SP, Brazil.ORCID http://orcid.org/0000-0001-8877-3160
Adalberto Luiz RosaBone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Av Do Café S/N, Ribeirão Preto, SP, 14040-904, Brazil.ORCID http://orcid.org/0000-0002-6495-2778
Marcio Mateus BelotiBone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Av Do Café S/N, Ribeirão Preto, SP, 14040-904, Brazil. mmbeloti@usp.br.ORCID http://orcid.org/0000-0003-0149-7189
Universidade de São Paulo · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade de Ribeirão Preto · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 140942/2016-5Conselho Nacional de Desenvolvimento Científico e Tecnológico 301496/2019-6Conselho Nacional de Desenvolvimento Científico e Tecnológico 403328/2016-0Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR) 303464/2016-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/13320-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/50333-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/12622-7Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/20349-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/11069-5Red Iberomericana de Alimentos Autoctonos Subutilizados 118RT0543
6 · The paper itself

Abstract

introductionThe jabuticaba peel extract (JPE) contains bioactive compounds that regulate fat metabolism. Because the negative correlation between fat accumulation and bone formation in bone marrow, we hypothesized that JPE inhibits adipocyte as well as favors osteoblast differentiation of mesenchymal stromal cells (MSCs) under healthy and osteoporotic conditions, a disease that display an imbalance between adipocyte and osteoblast differentiation resulting in reduced bone mass. MATERIAL AND

methodsTo test these hypotheses, bone marrow MSCs were harvested from healthy and osteoporotic rats and cultured in adipogenic and osteogenic media with three concentrations of JPE, 0.25, 5 and 10 µg/ml, and vehicle (control). After selecting the most efficient concentrations of JPE, we used them to evaluate adipocyte and osteoblast differentiation of MSCs from both sources.

resultsWe observed that, in general, JPE inhibited adipocyte differentiation of MSCs with more pronounced effects in cells from healthy than osteoporotic rats. In addition, JPE increased osteoblast differentiation, exhibiting a slightly higher osteogenic potential on MSCs from osteoporotic compared to healthy condition.

conclusionOur results demonstrated that JPE drives MSCs to inhibit adipocyte differentiation and toward osteoblast differentiation under healthy and osteoporotic conditions. These findings pave the way for further translational studies to investigate the therapeutic possibilities of JPE in both prevention and treatment of osteoporosis.

Indexed as

AdipocytesAdipogenesisAnimalsBone and BonesBone MarrowBone Marrow CellsCell DifferentiationCells, CulturedFemaleMesenchymal Stem CellsOsteoblastsOsteogenesisOsteoporosisOvariectomyPlant ExtractsRatsPlant ExtractsAdipocyteJabuticabaMesenchymal stromal cellOsteoblastOsteoporosis

Identifiers

PMID32889573
OpenAlexW3083399747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.