ArticleNeuroImage. Clinical2020
Increased iron-deposition in lateral-ventral substantia nigra pars compacta: A promising neuroimaging marker for Parkinson's disease.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Generating R2Medical physics · 2026Article
- Marine bacterium Stutzerimonas stutzeri mitigates Parkinson's disease pathology in C. elegans via ferroptosis modulation.Scientific reports · 2026Article
- From dysbiosis to dysfunction: specific gut microbes and metabolites in the pathogenesis of Parkinson's disease.Sustainable microbiology · 2026Review
- Ferroptosis and Iron Homeostasis: Molecular Mechanisms and Neurodegenerative Disease Implications.Antioxidants (Basel, Switzerland) · 2025Review
- Diffusion tensor image analysis along the perivascular space and quantitative susceptibility mapping in the diagnosis and severity assessment of Parkinson's disease.Quantitative imaging in medicine and surgery · 2025Article
- Natural flavonoids from herbs and nutraceuticals as ferroptosis inhibitors in central nervous system diseases: current preclinical evidence and future perspectives.Frontiers in pharmacology · 2025Review
- The Neural Palette of Heme: Altered Heme Homeostasis Underlies Defective Neurotransmission, Increased Oxidative Stress, and Disease Pathogenesis.Antioxidants (Basel, Switzerland) · 2024Review
- Zeolite and Neurodegenerative Diseases.Molecules (Basel, Switzerland) · 2024Review
- The Irony of Iron: The Element with Diverse Influence on Neurodegenerative Diseases.International journal of molecular sciences · 2024Review
- A more objective PD diagnostic model: integrating texture feature markers of cerebellar gray matter and white matter through machine learning.Frontiers in aging neuroscience · 2024Article
- The Construction and Validation of a Novel Ferroptosis-Related Gene Signature in Parkinson's Disease.International journal of molecular sciences · 2023Article
- The critical role of gut-brain axis microbiome in mental disorders.Metabolic brain disease · 2023Review
- Brainstem neuromelanin and iron MRI reveals a precise signature for idiopathic and LRRK2 Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Article
- Automatic detection of neuromelanin and iron in the midbrain nuclei using a magnetic resonance imaging-based brain template.Human brain mapping · 2022Article
- An Updated Overview of the Magnetic Resonance Imaging of Brain Iron in Movement Disorders.Behavioural neurology · 2022Review
- Nigral volumetric and microstructural measures in individuals with scans without evidence of dopaminergic deficit.Frontiers in neuroscience · 2022Article
- Low plasma serotonin linked to higher nigral iron in Parkinson's disease.Scientific reports · 2021Article
- Stability of AI-Enabled Diagnosis of Parkinson's Disease: A Study Targeting Substantia Nigra in Quantitative Susceptibility Mapping Imaging.Frontiers in neuroscience · 2021Article
- Nigral diffusivity, but not free water, correlates with iron content in Parkinson's disease.Brain communications · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundTo date there are no validated MRI biomarkers to assist diagnosis of Parkinson's disease (PD). Our aim was to investigate PD related iron changes in the substantia nigra pars compacta (SNpc) as defined by neuromelanin-sensitive MR contrast.
methodsThirty-nine PD participants and 33 healthy controls were scanned at 3.0-T using a 16-echo gradient echo sequence to create R
resultsPD related iron changes mostly occur in the lateral-ventral part of the neuromelanin SNpc. The R
conclusionThe overlap between the iron content as determined by R
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.