GuidelineChest2021
Global Physiology and Pathophysiology of Cough: Part 1: Cough Phenomenology - CHEST Guideline and Expert Panel Report.
Guideline in Chest, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Cough biomarkers for diagnosis and monitoring of respiratory disease: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Cough monitoring systems in adults with chronic respiratory diseases: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- The effect of respiratory muscle training on children and adolescents with cystic fibrosis: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- Prevalence of chronic cough in China: a systematic review and meta-analysis.BMC pulmonary medicine · 2022Pooled it
- A systematic review and meta-analysis of prevalence of complications after tracheal stenting in dogs.Journal of veterinary internal medicinePooled it
- The efficacy and safety of duloxetine in treating refractory chronic cough: a randomized clinical trial.BMC medicine · 2026Trial
- Trial
- Biomechanical Behavior of an Aged Synthetic Hernia Mesh Under a Cough-Simulating Protocol.Materials (Basel, Switzerland) · 2026Article
- Beyond fingerprint and voice print: cough sequence sound for identity verification.npj health systems · 2026Article
- Bone Turnover Markers as Biomarkers of Cough Dysfunction and Respiratory Risk in Subacute Ischemic Stroke.Diagnostics (Basel, Switzerland) · 2026Article
- Ambroxol hydrochloride and clenbuterol hydrochloride oral solution for wheezing disorders in children in China: evidence mapping and meta-analysis.Frontiers in pediatrics · 2026Article
- Beyond codeine - the evidence landscape of conventional, natural, and emerging antitussive therapies: a systematic review and meta-analysis.Frontiers in pharmacology · 2026Article
- Case Report: Early diaphragmatic plication for combined phrenic and recurrent laryngeal nerve injury after VATS thymectomy.Frontiers in medicine · 2026Article
- A cross sectional feasibility study to evaluate the usability and efficacy of Swaasa AI platform for rapid respiratory health assessment.Scientific reports · 2025Article
- Comparative Analysis of Classic and Novel Antitussives on Cough Suppression in Guinea Pigs.Pharmaceutics · 2025Article
- Pathophysiology, Clinical Heterogeneity, and Therapeutic Advances in Amyotrophic Lateral Sclerosis: A Comprehensive Review of Molecular Mechanisms, Diagnostic Challenges, and Multidisciplinary Management Strategies.Life (Basel, Switzerland) · 2025Review
- Clinical characteristics of the early responders in the treatment of chronic cough.Journal of thoracic disease · 2025Article
- Prevalence and risk factors of chronic cough in an adult community-dwelling Portuguese population.ERJ open research · 2025Article
- Persistent cough after segmental resection, an issue that clinicians need to pay more attention to.Frontiers in oncology · 2025Article
- Early postoperative patient-reported outcomes in thoracoscopic segmentectomy: a comparative study of non-intubated anesthesia versus intubated general anesthesia.Frontiers in oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The purpose of this state-of-the-art review is to update the American College of Chest Physicians 2006 guideline on global physiology and pathophysiology of cough. A review of the literature was conducted using PubMed and MEDLINE databases from 1951 to 2019 and using prespecified search terms. We describe the basic phenomenology of cough patterns, behaviors, and morphological features. We update the understanding of mechanical and physiological characteristics of cough, adding a contemporary view of the types of cough and their associated behaviors and sensations. New information about acoustic characteristics is presented, and recent insights into cough triggers and the patient cough hypersensitivity phenotype are explored. Lastly, because the clinical assessment of patients largely focuses on the duration rather than morphological features of cough, we review the morphological features of cough that can be measured in the clinic. This is the first of a two-part update to the American College of Chest Physicians 2006 cough guideline; it provides a more global consideration of cough phenomenology, beyond simply the mechanical aspects of a cough. A greater understanding of the typical features of cough, and their variations, may allow a more informed interpretation of cough measurements and the clinical relevance for patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.