Evidence map›Paper›PMID 32888876›Full record

ArticleOral surgery, oral medicine, oral pathology and oral radiology2021

Oral lesions in patients with SARS-CoV-2 infection: could the oral cavity be a target organ?

Thaís Bianca Brandão, Luiz Alcino Gueiros, Thayanara Silva Melo, Ana Carolina Prado-Ribeiro, Ana Cristina Froelich Alo Nesrallah, Gladys Villas Boas Prado, Alan Roger Santos-Silva, Cesar Augusto Migliorati

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PubMed Full text at PMC Publisher
In one paragraph

Article in Oral surgery, oral medicine, oral pathology and oral radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 11 pooled it
30.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 11 syntheses or guidelines pooled it, 224 citations in OpenAlex.

  1. Pooled it
  2. Oral mucosa lesions in confirmed and non-vaccinated cases for COVID-19: A systematic review.Journal of stomatology, oral and maxillofacial surgery · 2022
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  7. Oral Manifestations of COVID-19 in Hospitalized Patients: A Systematic Review.International journal of environmental research and public health · 2021
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  8. Oral mucosal lesions in patients with COVID-19: a systematic review.The British journal of oral & maxillofacial surgery · 2021
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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Thaís Bianca BrandãoOral Medicine Department, Hospital Sírio-Libanês, São Paulo, Brazil; Dental Oncology Service, Instituto do Câncer do Estado de São Paulo (ICESP-FMUSP), São Paulo, Brazil. Electronic address: thais.brandao@hsl.org.br.
Luiz Alcino GueirosDepartamento de Clínica e Odontologia Preventiva, Universidade Federal de Pernambuco, Recife, Brazil.
Thayanara Silva MeloDepartamento de Clínica e Odontologia Preventiva, Universidade Federal de Pernambuco, Recife, Brazil.
Ana Carolina Prado-RibeiroDental Oncology Service, Instituto do Câncer do Estado de São Paulo (ICESP-FMUSP), São Paulo, Brazil; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Ana Cristina Froelich Alo NesrallahOral Medicine Department, Hospital Sírio-Libanês, São Paulo, Brazil.
Gladys Villas Boas PradoInfectious Diseases Department, Hospital Sírio-Libanês, São Paulo, Brazil.
Alan Roger Santos-SilvaOral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Cesar Augusto MiglioratiCollege of Dentistry, University of Florida, Gainesville, FL, USA.
Hospital Sírio-Libanês · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal de Pernambuco · BRInstituto do Câncer do Estado de São Paulo · BRUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several viruses transmitted through saliva, such as herpes simplex virus, cytomegalovirus, and Zika virus, are capable of infecting and replicating in the oral mucosa, leading to painful oral ulcers. Few studies have described the oral manifestations of coronavirus disease 2019 (COVID-19). There is growing evidence that angiotensin-converting enzyme 2 (ACE2), the main host cell receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is highly expressed on the epithelial cells of the tongue and of the salivary glands, which may explain the development of dysgeusia in patients with COVID-19. Hence, it is important to understand if SARS-CoV-2 can infect and replicate in oral keratinocytes and fibroblasts, causing oral ulcerations and superficial necrosis. Here, we report a series of 8 cases of COVID-19 infection, with oral necrotic ulcers and aphthous-like ulcerations which developed early in the course of disease after the development of dysgeusia and affected the tongue, lips, palate, and oropharynx. A short review of the literature regarding the important role of ACE2 in SARS-CoV-2 cellular entry is also provided, bringing new insights into oral keratinocytes and minor salivary glands as potential targets.

Indexed as

COVID-19Oral UlcerZika VirusZika Virus InfectionHumansPeptidyl-Dipeptidase ASalivaSARS-CoV-2Peptidyl-Dipeptidase A

Identifiers

PMID32888876
PMCPMC7434495
OpenAlexW3068149963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.