Evidence map›Paper›PMID 32888717›Full record

ArticleTrends in neurosciences2020

Protecting Connections from Synapse Elimination.

Gabrielle L Sell, A Kimberley McAllister

Open access · greenAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in neurosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Gabrielle L SellCenter for Neuroscience, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.
A Kimberley McAllisterCenter for Neuroscience, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA. Electronic address: kmcallister@ucdavis.edu.
University of California, Davis · US

Funding

UC Davis Conte Center: Neuroimmune Mechanisms of Psychiatric DisordersP50MH106438 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARTER, CAMERON S. · 2015 to 2025
$26.1M
Immune Molecules in Early Postnatal Nervous System DevelopmentR01NS060125 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MCALLISTER, A KIMBERLEY · 2010 to 2019
$3.3M
Neuroscience of Cognitive AgingT32AG050061 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DECARLI, CHARLES · 2016 to 2020
$869k
Prenatal brain development following maternal immune activationR21MH116681 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MCALLISTER, A KIMBERLEY, NORD, ALEXANDER · 2018 to 2019
$432k
MHCI and synapse loss in Alzheimer's disease modelsR21AG071884 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MCALLISTER, A KIMBERLEY · 2022 to 2022
$424k
NIA NIH HHS R21 AG071884NIA NIH HHS T32 AG050061NIMH NIH HHS P50 MH106438NIMH NIH HHS R21 MH116681NINDS NIH HHS R01 NS060125
6 · The paper itself

Abstract

A recent paper by Cong et al. provides exciting evidence that neurons contain proteins that protect synapses from complement-mediated synapse elimination. SRPX2 binds C1q and blocks microglial synapse engulfment. The findings point at SRPX2, and potentially other related sushi domain proteins, as possible targets for therapies for neurodevelopmental and neurodegenerative disorders.

Indexed as

NeuronsSynapsesComplement System ProteinsMicrogliaComplement System ProteinsC1qC3complementSRPX2sushi domain proteinsynapse elimination

Identifiers

PMID32888717
PMCPMC9934306
OpenAlexW3082352558

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.