Evidence map›Paper›PMID 32888706›Full record

ReviewPathology2020

SARS-CoV-2 in children: spectrum of disease, transmission and immunopathological underpinnings.

Phoebe C M Williams, Annaleise R Howard-Jones, Peter Hsu, Pamela Palasanthiran, Paul E Gray, Brendan J McMullan, Philip N Britton, Adam W Bartlett

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Phoebe C M WilliamsDepartment of Immunology and Infectious Diseases, Sydney Children's Hospital, Randwick, NSW, Australia; School of Women's and Children's Health, UNSW Sydney, NSW, Australia.
Annaleise R Howard-JonesDepartment of Infectious Diseases and Microbiology, The Children's Hospital at Westmead, NSW, Australia.
Peter HsuDepartment of Allergy and Immunology and Kids Research, The Children's Hospital at Westmead, NSW, Australia; Discipline of Child and Adolescent Health, University of Sydney, NSW, Australia.
Pamela PalasanthiranDepartment of Immunology and Infectious Diseases, Sydney Children's Hospital, Randwick, NSW, Australia; School of Women's and Children's Health, UNSW Sydney, NSW, Australia.
Paul E GrayDepartment of Immunology and Infectious Diseases, Sydney Children's Hospital, Randwick, NSW, Australia; School of Women's and Children's Health, UNSW Sydney, NSW, Australia.
Brendan J McMullanDepartment of Immunology and Infectious Diseases, Sydney Children's Hospital, Randwick, NSW, Australia; School of Women's and Children's Health, UNSW Sydney, NSW, Australia.
Philip N BrittonDepartment of Infectious Diseases and Microbiology, The Children's Hospital at Westmead, NSW, Australia; Discipline of Child and Adolescent Health, University of Sydney, NSW, Australia; Marie Bashir Institute, University of Sydney, NSW, Australia.
Adam W BartlettDepartment of Immunology and Infectious Diseases, Sydney Children's Hospital, Randwick, NSW, Australia; School of Women's and Children's Health, UNSW Sydney, NSW, Australia. Electronic address: adam.bartlett@health.nsw.gov.au.
UNSW Sydney · AUThe University of Sydney · AUChildren's Hospital at Westmead · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the SARS-CoV-2 pandemic unfolds across the globe, consistent themes are emerging with regard to aspects of SARS-CoV-2 infection and its associated disease entities in children. Overall, children appear to be less frequently infected by, and affected by, SARS-CoV-2 virus and the clinical disease COVID-19. Large epidemiological studies have revealed children represent less than 2% of the total confirmed COVID-19 cases, of whom the majority experience minimal or mild disease that do not require hospitalisation. Children do not appear to be major drivers of SARS-CoV-2 transmission, with minimal secondary virus transmission demonstrated within families, schools and community settings. There are several postulated theories regarding the relatively low SARS-CoV-2 morbidity and mortality seen in children, which largely relate to differences in immune responses compared to adults, as well as differences in angiotensin converting enzyme 2 distribution that potentially limits viral entry and subsequent inflammation, hypoxia and tissue injury. The recent emergence of a multisystem inflammatory syndrome bearing temporal and serological plausibility for an immune-mediated SARS-CoV-2-related disease entity is currently under investigation. This article summarises the current available data regarding SARS-CoV-2 and the paediatric population, including the spectrum of disease in children, the role of children in virus transmission, and host-virus factors that underpin the unique aspects of SARS-CoV-2 pathogenicity in children.

Indexed as

ChildChild, PreschoolCOVID-19FemaleHost-Pathogen InteractionsHumansInfantMaleSARS-CoV-2ACE2COVID-19multisystem inflammatory syndromepaediatricsSARS-CoV-2transmission

Identifiers

PMID32888706
PMCPMC7437539
OpenAlexW3049744677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.