Evidence map›Paper›PMID 32888493›Full record

SynthesisCell2020

Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.

Ming-Huei Chen, Laura M Raffield, Abdou Mousas, Saori Sakaue, Jennifer E Huffman, Arden Moscati, Bhavi Trivedi, Tao Jiang, Parsa Akbari, Dragana Vuckovic and 101 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 436 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
436citing papers in PubMed, 14 pooled it
68.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

436 citing papers in PubMed, 14 syntheses or guidelines pooled it, 712 citations in OpenAlex.

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  13. Genome-Wide Search for Nonadditive Allele Effects IdentifiesJournal of the American Heart Association · 2024
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376 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

111 authors at 20 institutions in 12 countries.

Ming-Huei ChenThe Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, MA 01702, USA; Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham, MA 01702, USA.
Laura M RaffieldDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Abdou MousasMontreal Heart Institute, Montreal, QC H1T 1C8, Canada.
Saori SakaueDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
Jennifer E HuffmanMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA.
Arden MoscatiThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Bhavi TrivediBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
Tao JiangBHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Parsa AkbariBHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; MRC Biostatistics Unit, University of Cambridge, Cambridge CB2 0SR, UK; Human Genetics, Wellcome Sanger Institute, Hinxton CB10 1SA, UK; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge CB2 0QQ, UK.
Dragana VuckovicHuman Genetics, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
Erik L BaoDivision of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02446, USA.
Xue ZhongDivision of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
Regina ManansalaZilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA.
Véronique LaplanteDépartement de Pharmacologie et Physiologie, Faculty of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada.
Minhui ChenCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Ken Sin LoMontreal Heart Institute, Montreal, QC H1T 1C8, Canada.
Huijun QianDepartment of Statistics and Operation Research, University of North Carolina, Chapel Hill, NC 27599, USA.
Caleb A LareauDivision of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02446, USA.
Mélissa BeaudoinMontreal Heart Institute, Montreal, QC H1T 1C8, Canada.
Karen A HuntBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
Masato AkiyamaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan; Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8581, Japan.
Traci M BartzDepartment of Biostatistics, University of Washington, Seattle, WA 98101, USA.
Yoav Ben-ShlomoPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2PS, UK.
Andrew BeswickTranslational Health Sciences, Musculoskeletal Research Unit, Bristol Medical School, University of Bristol, Bristol BS10 5NB, UK.
Jette Bork-JensenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
Erwin P BottingerThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Hasso-Plattner-Institut, Universität Potsdam, Potsdam 14469, Germany.
Jennifer A BrodyDepartment of Medicine, University of Washington, Seattle, WA 98101, USA.
Frank J A van RooijDepartment of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam 3015, the Netherlands.
Kumaraswamynaidu ChitralaLaboratory of Epidemiology and Population Science, National Institute on Aging/NIH, Baltimore, MD 21224, USA.
Kelly ChoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA; Department of Medicine, Division on Aging, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Hélène ChoquetDivision of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA.
Adolfo CorreaDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
John DaneshBHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; Human Genetics, Wellcome Sanger Institute, Hinxton CB10 1SA, UK; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge CB2 0QQ, UK; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge CB10 1SA, UK; National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge University Hospitals, Cambridge CB2 0QQ, UK; British Heart Foundation Centre of Research Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
Emanuele Di AngelantonioBHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge CB2 0QQ, UK; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge CB10 1SA, UK; National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge University Hospitals, Cambridge CB2 0QQ, UK; British Heart Foundation Centre of Research Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
Niki DimouSection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon 69008, France; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina 45110, Greece.
Jingzhong DingDepartment of Internal Medicine, Section of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA.
Paul ElliottDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Imperial Biomedical Research Centre, Imperial College London and Imperial College NHS Healthcare Trust, London SW7 2AZ, UK; Medical Research Council-Public Health England Centre for Environment, Imperial College London, London SW7 2AZ, UK; UK Dementia Research Institute, Imperial College London, London SW7 2AZ, UK; Health Data Research UK - London, London SW7 2AZ, UK.
Tõnu EskoBroad Institute of Harvard and MIT, Cambridge, MA 02446, USA.
Michele K EvansLaboratory of Epidemiology and Population Science, National Institute on Aging/NIH, Baltimore, MD 21224, USA.
James S FloydDepartment of Medicine, University of Washington, Seattle, WA 98101, USA; Department of Epidemiology, University of Washington, Seattle, WA 98101, USA.
Linda BroerDepartment of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam 3015, the Netherlands.
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
Michael H GuoBroad Institute of Harvard and MIT, Cambridge, MA 02446, USA; Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Andreas GreinacherInstitute for Immunology and Transfusion Medicine, University Medicine Greifswald, Greifswald 17475, Germany.
Jeff HaesslerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
Joanna M M HowsonBHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; Novo Nordisk Research Centre Oxford, Innovation Building, Old Road Campus, Oxford OX3 7FZ, UK.
Qin Qin HuangHuman Genetics, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
Wei HuangDepartment of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center and Shanghai Industrial Technology Institute (SITI), Shanghai 201203, China.
Eric JorgensonDivision of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA.
Tim KacprowskiInterfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald 17475, Germany; Chair of Experimental Bioinformatics, Research Group Computational Systems Medicine, Technical University of Munich, Freising-Weihenstephan 85354, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald 17475, Germany.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere 33521, Finland; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere 33014, Finland.
Yoichiro KamataniLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo 108-8639, Japan.
Masahiro KanaiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Savita KarthikeyanBHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Fotis KoskeridisDepartment of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina 45110, Greece.
Leslie A LangeDepartment of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere 33014, Finland.
Markus M LerchDepartment of Internal Medicine, University Medicine Greifswald, Greifswald 17475, Germany.
Allan LinnebergCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg 2000, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
Yongmei LiuDuke Molecular Physiology Institute, Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC 27701, USA.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere 33014, Finland.
Ani ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, VA 22903, USA.
Hilary C MartinHuman Genetics, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
Koichi MatsudaDepartment of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo 108-8639, Japan.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Nina MononenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere 33014, Finland.
Yoshinori MurakamiDivision of Molecular Pathology, The Institute of Medical Sciences, The University of Tokyo, Tokyo 108-8639, Japan.
Girish N NadkarniThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Matthias NauckGerman Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald 17475, Germany; Institue of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald 17475, Germany.
Kjell NikusDepartment of Cardiology, Heart Center, Tampere University Hospital, Tampere 33521, Finland; Department of Cardiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere 33014, Finland.
Willem H OuwehandHuman Genetics, Wellcome Sanger Institute, Hinxton CB10 1SA, UK; British Heart Foundation Centre of Research Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK; Department of Hematology, University of Cambridge, Cambridge CB2 0PT, UK; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK.
Nathan PankratzDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
Michael PreussThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Bruce M PsatyDepartment of Medicine, University of Washington, Seattle, WA 98101, USA; Department of Epidemiology, University of Washington, Seattle, WA 98101, USA; Department of Health Services, University of Washington, Seattle, WA 98101, USA; Kaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA.
Olli T RaitakariCentre for Population Health Research, University of Turku and Turku University Hospital, Turku 20521, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20521, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland.
David J RobertsThe National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge CB2 0QQ, UK; Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK; Department of Haematology, Churchill Hospital, Oxford OX3 7LE, UK; NHS Blood and Transplant - Oxford Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA 22903, USA.
Benjamin A T RodriguezThe Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, MA 01702, USA; Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham, MA 01702, USA.
Jonathan D RosenDepartment of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Petra SchubertMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA.
Cassandra N SpracklenDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA 01002, USA.
Praveen SurendranBHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; Rutherford Fund Fellow, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Hua TangDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jean-Claude TardifMontreal Heart Institute, Montreal, QC H1T 1C8, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada.
Richard C TrembathSchool of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London SE1 1UL, UK.
Mohsen GhanbariDepartment of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam 3015, the Netherlands; Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran.
Uwe VölkerInterfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald 17475, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald 17475, Germany.
Henry VölzkeGerman Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald 17475, Germany; Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany.
Nicholas A WatkinsNational Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK.
Alan B ZondermanLaboratory of Epidemiology and Population Science, National Institute on Aging/NIH, Baltimore, MD 21224, USA.
VA Million Veteran Program
Peter W F WilsonAtlanta VA Medical Center, Decatur, GA 30033, USA.
Yun LiDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA.
Adam S ButterworthBHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge CB2 0QQ, UK; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge CB10 1SA, UK.
Jean-François GauchatDépartement de Pharmacologie et Physiologie, Faculty of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada.
Charleston W K ChiangCenter for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA; Quantitative and Computational Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Bingshan LiDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
William J AstleMRC Biostatistics Unit, University of Cambridge, Cambridge CB2 0SR, UK; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge CB2 0QQ, UK; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Strangeways Laboratory, Cambridge CB1 8RN, UK.
Evangelos EvangelouDepartment of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina 45110, Greece; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
David A van HeelBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
Vijay G SankaranDivision of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02446, USA.
Yukinori OkadaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan; Laboratory of Statistical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
Nicole SoranzoHuman Genetics, Wellcome Sanger Institute, Hinxton CB10 1SA, UK; Department of Hematology, University of Cambridge, Cambridge CB2 0PT, UK.
Andrew D JohnsonThe Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, MA 01702, USA; Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham, MA 01702, USA.
Alexander P ReinerDepartment of Epidemiology, University of Washington, Seattle, WA 98109, USA.
Paul L AuerZilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA. Electronic address: pauer@uwm.edu.
Guillaume LettreMontreal Heart Institute, Montreal, QC H1T 1C8, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada. Electronic address: guillaume.lettre@umontreal.ca.
University of Cambridge · GBUniversitätsmedizin Greifswald · DEUniversity of North Carolina at Chapel Hill · USIcahn School of Medicine at Mount Sinai · USMontreal Heart Institute · CAUniversity of Copenhagen · DKUniversity of Washington · USBroad Institute · USNational Institute on Aging · USQueen Mary University of London · GBRIKEN Center for Integrative Medical Sciences · JPUniversité de Montréal · CAVA Boston Healthcare System · USWellcome Sanger Institute · GBErasmus MC · NLHealth Data Research UK · GBKaiser Permanente · USNational Heart Lung and Blood Institute · USTampere University · FIThe University of Tokyo · JP

Funding

CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
Next generation functional genomics of hematology traitsR01HL146500 · NHLBI · UNIVERSITY OF WASHINGTON · PI ALEXANDER P REINER · 2020 to 2026
$5.7M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
WGA Study to Identify Genetic Variants Associated with CV Events in CHSR01HL087652 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2007 to 2009
$5.1M
Sequence analysis of hemotological traits in African AmericansR01HL130733 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LANGE, ETHAN MATHER, REINER, ALEXANDER P · 2016 to 2019
$2.7M
From gene regions to whole chromosomes: scaling up association-finding for disease and omics outcomes in TOPMedU01HL137162 · NHLBI · UNIVERSITY OF WASHINGTON · PI RICE, KENNETH M. · 2017 to 2019
$1.6M
BLRD VA I01 BX003340Medical Research Council MR/R023484/1Medical Research Council MR/S019669/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/P001076/1NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL130733NHLBI NIH HHS R01 HL146500NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NHLBI NIH HHS U01 HL137162Wellcome Trust 210561/Z/18/ZWorld Health Organization 001
6 · The paper itself

Abstract

Most loci identified by GWASs have been found in populations of European ancestry (EUR). In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including 184,535 non-EUR individuals, we identified 5,552 trait-variant associations at p < 5 × 10

Indexed as

Asian PeopleGeneticsGenome-Wide Association StudyHEK293 CellsHumansInterleukin-7Mutation, MissensePhenotypePolymorphism, Single NucleotideWhite PeopleInterleukin-7interleukin-7, genetic architecture, fine-mapping, selective sweeps, polygenic trait score, phenome-wide association study

Identifiers

PMID32888493
PMCPMC7480402
OpenAlexW3082575318

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.