ArticleNeuron2020
Processing in Lateral Orbitofrontal Cortex Is Required to Estimate Subjective Preference during Initial, but Not Established, Economic Choice.
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Chemogenetic inhibition of the ventrolateral orbitofrontal cortex disrupts novelty-guided updating of spatial memories and alters hippocampal engram reactivation.Psychopharmacology · 2026Article
- Control of associative learning by the mediodorsal thalamus-orbitofrontal cortex circuit.Nature communications · 2026Article
- A corticostriatal circuit updates subjective beliefs about latent task states.bioRxiv : the preprint server for biology · 2026Article
- Persistent representation of a prior schema in the orbitofrontal cortex facilitates learning of a conflicting schema.Nature communications · 2026Article
- Dopaminergic responses to identity prediction errors depend differently on the orbitofrontal cortex and hippocampus.Behavioral neuroscience · 2026Article
- Distinct contributions of anterior and posterior orbitofrontal cortex to outcome-guided behavior.bioRxiv : the preprint server for biology · 2025Article
- Parallel neuronal structural plasticity with memory trace formation in the orbitofrontal cortex.Nature communications · 2025Article
- Article
- Higher-order and distributed synergistic functional interactions encode information gain in goal-directed learning.Nature communications · 2025Article
- [Synchronized neural rhythms in rat hippocampal CA1 region and orbitofrontal cortex are involved in learning and memory consolidation in spatial goal-directed tasks].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Effects of three exercise interventions on inhibitory control in college students with internet addiction: a functional near-infrared spectroscopy study.Frontiers in psychology · 2025Article
- The representation of decision variables in orbitofrontal cortex is longitudinally stable.Cell reports · 2024Article
- Functional specialization of medial and lateral orbitofrontal cortex in inferential decision-making.iScience · 2024Article
- Transcriptomic effects of paternal cocaine-seeking on the reward circuitry of male offspring.Translational psychiatry · 2024Article
- The orbitofrontal cortex: A goal-directed cognitive map framework for social and non-social behaviors.Neurobiology of learning and memory · 2023Review
- Orbitofrontal cortex control of striatum leads economic decision-making.Nature neuroscience · 2023Article
- The role of the lateral orbitofrontal cortex in creating cognitive maps.Nature neuroscience · 2023Article
- Review
- Article
- Taking stock of value in the orbitofrontal cortex.Nature reviews. Neuroscience · 2022Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The orbitofrontal cortex (OFC) is proposed to be critical to economic decision making. Yet one can inactivate OFC without affecting well-practiced choices. One possible explanation of this lack of effect is that well-practiced decisions are codified into habits or configural-based policies not normally thought to require OFC. Here, we tested this idea by training rats to choose between different pellet pairs across a set of standard offers and then inactivating OFC subregions during choices between novel offers of previously experienced pairs or between novel pairs of previously experienced pellets. Contrary to expectations, controls performed as well on novel as experienced offers yet had difficulty initially estimating their subjective preference on novel pairs, difficulty exacerbated by lateral OFC inactivation. This pattern of results indicates that established economic choice reflects the use of an underlying model or goods space and that lateral OFC is only required for normal behavior when the established framework must incorporate new information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.