ArticleTransboundary and emerging diseases2021
Phylogenetic relationships investigation of Mycobacterium caprae strains from sympatric wild boar and goats based on whole genome sequencing.
Article in Transboundary and emerging diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 18 citations in OpenAlex.
- Nationwide seroprevalence ofFrontiers in microbiology · 2026Article
- M. caprae in northern Italy: a comprehensive analysis through whole-genome sequencing on the genetic variability in bovine herds.Veterinary research · 2025Article
- Zoonotic tuberculosis in Catalonia, Spain: Phylogenetic insights intoOne health (Amsterdam, Netherlands) · 2025Article
- Long-Term Residual Infection as a Source of Bovine Tuberculosis Reemergence: A Phylogenetic and Epidemiological Investigation of Recurrent Outbreaks.Transboundary and emerging diseases · 2025Article
- Detection ofFrontiers in microbiology · 2024Article
- Article
- A One Health approach revealed the long-term role ofEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023Article
- Generalized tuberculosis due to Mycobacterium caprae in a red fox phylogenetically related to livestock breakdowns.BMC veterinary research · 2022Article
- Health status of free-ranging pure and cross-mixed miniature swine population from Northeast Spain.Veterinary medicine and science · 2022Article
- Whole-Genome SNP Analysis Identifies PutativeMicroorganisms · 2021Article
- Phylogenetic relationships investigation of Mycobacterium caprae strains from sympatric wild boar and goats based on whole genome sequencing.Transboundary and emerging diseases · 2021Article
- A new nomenclature for the livestock-associatedOpen research Europe · 2021Article
- Long-term efficacy of BCG vaccination in goat herds with a high prevalence of tuberculosis.Scientific reports · 2020Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tuberculosis (TB) in wildlife challenges epidemiological surveillance and disease control. An outbreak of TB was detected in a free-ranging wild boar population of a Natural Park in Catalonia (Spain) and the outbreak investigation was conducted in the area. During the study period (2015-2020), 278 wild boars were analysed by gross pathology, histopathology, mycobacterial culture and DVR-spoligotyping. In addition, all cattle (49) and goat (47) herds of the area were tested with tuberculin skin test. TB compatible lesions were detected in 21 wild boars, and Mycobacterium caprae was isolated in 17 of them with two different spoligotypes: SB0415 (13) and SB1908 (4). Only two goat herds showed TB positive animals that were subsequently slaughtered. M. caprae with the spoligotypes SB0416 and SB0415 were isolated from these animals. To investigate the phylogenetic relationships and the transmission chain of the outbreak, nine strains isolated from six wild boars and three goats of the study area were analysed by whole genome sequencing (WGS) followed by single nucleotide polymorphism (SNP) analysis by maximum likelihood and median-joining network inference methods. Results indicated that infected wild boars maintained M. caprae strains circulation in their own population and have likely transmitted the infection to goats, thus acting as TB reservoirs, compromising the success of livestock TB eradication campaigns and posing a risk for public health. The results also highlighted the usefulness of WGS followed by SNP analysis in providing relevant epidemiological information when detailed contact data are missing.
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