ArticleJournal of biomedical optics2020
Photoacoustics resolves species-specific differences in hemoglobin concentration and oxygenation.
Article in Journal of biomedical optics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- OpenQPAIData: Measurements of test objects with reference labels for quantitative photoacoustic imaging research.Scientific data · 2026Article
- Xeno-learning: knowledge transfer across species in deep learning-based spectral image analysis.Nature biomedical engineering · 2026Article
- Diode-based photoacoustic imaging for monitoring therapeutic response in rheumatoid arthritis.Biomedical optics express · 2025Article
- Non-invasive quantification of total hemoglobin concentrations by visible-light spectroscopic optical coherence tomography: a validation study on healthy volunteers.Biomedical optics express · 2025Article
- Chip-Based Optoacoustic Single-Cell Detection in Flow Using Point-Source Optimized Surface Acoustic Wave Transducers.ACS applied materials & interfaces · 2025Article
- Nanophotonic-enhanced photoacoustic imaging for brain tumor detection.Journal of nanobiotechnology · 2025Review
- Effects of skin tone on photoacoustic imaging and oximetry.Journal of biomedical optics · 2024Article
- Characterizing a photoacoustic and fluorescence imaging platform for preclinical murine longitudinal studies.Journal of biomedical optics · 2023Article
- Multispectral optoacoustic tomography for the non-invasive identification of patients with severe anemia in vivo.Photoacoustics · 2022Article
- 3D Ultrasound-Guided Photoacoustic Imaging to Monitor the Effects of Suboptimal Tyrosine Kinase Inhibitor Therapy in Pancreatic Tumors.Frontiers in oncology · 2022Article
- SVD-based filtering to detect intraplaque hemorrhage using single wavelength photoacoustic imaging.Journal of biomedical optics · 2021Article
- Optoacoustic Imaging in Inflammation.Biomedicines · 2021Review
- Learned spectral decoloring enables photoacoustic oximetry.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
significancePhotoacoustic imaging (PAI) enables the detection of blood hemoglobin (HB) concentration and oxygenation (sO2) with high contrast and resolution. Despite the heavy use of photoacoustically determined total hemoglobin (THb) and oxygenation (sO2) biomarkers in PAI research, their relationship with underlying biochemical blood parameters and the impact of intra- and interspecies genetic variability have yet to be established.
aimTo explore the relationship between THb and sO2 photoacoustic biomarkers and the underlying biochemical blood parameters in a species-specific manner. APPROACH: Experiments were performed on blood in vitro using tissue-mimicking agar phantoms. Blood was extracted from mouse, rat, human, and naked mole-rat (Heterocephalus glaber), anticoagulated in ethylenediaminetetraacetic acid, and measured within 48 h. THb and sO2 were measured using a commercial photoacoustic tomography system (InVision 128, iThera Medical GmBH). Biochemical blood parameters such as HB concentration (g/dL), hematocrit (HCT, %), and red blood cell (RBC) count (μL - 1) were assessed using a hematology analyzer (Mythic 18 Vet, Woodley Equipment).
resultsA significant correlation was observed between THb and biochemical HB, HCT, and RBC in mouse and rat blood. Moreover, PAI accurately recapitulated interspecies variations in HB and HCT between mouse and rat blood and resolved differences in the oxygen dissociation curves measured using sO2 between human, mouse, and rat. With these validation data in hand, we applied PAI to studies of blood obtained from naked mole-rats and could confirm the high oxygen affinity of this species in comparison to other rodents of similar size.
conclusionsOur results demonstrate the high sensitivity of photoacoustically determined hemoglobin biomarkers toward species-specific variations in vitro.
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