Trial reportEuropean journal of pediatrics2021
Intravenous paracetamol in comparison with ibuprofen for the treatment of patent ductus arteriosus in preterm infants: a randomized controlled trial.
Trial report in European journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 5 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Heterogeneity in treatment response for patent ductus arteriosus: a meta-analysis.European journal of pediatrics · 2025Pooled it
- Use of NSAIDs and acetaminophen and risk of spontaneous intestinal perforations in premature infants: a systematic review and meta-analysis.Frontiers in pediatrics · 2024Pooled it
- Therapeutic Efficacy and Safety of Paracetamol versus Ibuprofen in Patent Ductus Arteriosus in Newborns: A Systematic Review.Arquivos brasileiros de cardiologia · 2024Pooled it
- Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants.The Cochrane database of systematic reviews · 2022Pooled it
- Efficacy and Costs of Three Pharmacotherapies for Patent Ductus Arteriosus Closure in Premature Infants.Paediatric drugs · 2022Pooled it
- Pharmacokinetics, dosing exposure and safety of oral ibuprofen in Chinese preterm neonates with patent ductus arteriosus: preliminary report.BMJ paediatrics open · 2026Trial
- Comparison of two targeted rescue treatments after the first week of expectant managment for very preterm infants with hemodynamically significant patent ductus arteriosus: a prospective study.Italian journal of pediatrics · 2026Trial
- Acetaminophen versus Ibuprofen for the management of hemodynamically significant patent ductus arteriosus in very low birth weight infants: randomized trial.Jornal de pediatriaTrial
- Evaluating the Effectiveness of Ibuprofen Versus Acetaminophen in Closing Patent Ductus Arteriosus in Preterm Neonates.Children (Basel, Switzerland) · 2026Article
- Trends in bronchopulmonary dysplasia and 15-year evolution in respiratory and hemodynamic management of very premature infants.Scientific reports · 2025Observational
- Second Attempt for Patent Ductus Arteriosus (PDA) Closure: Room for Acetaminophen? A Retrospective Single-Center Experience at Gaslini Children's Hospital.Children (Basel, Switzerland) · 2025Article
- Pharmacologic Management of Patent Ductus Arteriosus in the Neonatal Intensive Care Unit: A Retrospective Study.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025Article
- Response of the ductus arteriosus to acetaminophen or indomethacin in extremely low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- A comparison of different dosing regimen of intravenous paracetamol for hemodynamically significant patent ductus arteriosus closure in premature neonates <32 weeks: a prospective observational study.Journal of perinatology : official journal of the California Perinatal Association · 2024Observational
- Evaluation of the association between patent ductus arteriosus approach and neurodevelopment in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Pharmacological pain and sedation interventions for the prevention of intraventricular hemorrhage in preterm infants on assisted ventilation - an overview of systematic reviews.The Cochrane database of systematic reviews · 2023Review
- The Predictive Value of Lung Ultrasound Score on Hemodynamically Significant Patent Ductus Arteriosus among Neonates ≤25 Weeks.Diagnostics (Basel, Switzerland) · 2023Article
- Interventions for patent ductus arteriosus (PDA) in preterm infants: an overview of Cochrane Systematic Reviews.The Cochrane database of systematic reviews · 2023Review
- A Network Meta-Analysis of Intravenous Versus Oral Acetaminophen for Patent Ductus Arteriosus.Pediatric cardiology · 2023Review
- Comparison of lung ultrasound scores with clinical models for predicting bronchopulmonary dysplasia.European journal of pediatrics · 2023Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our aim was to assess the efficacy and safety of intravenous (i.v.) paracetamol vs. i.v. ibuprofen for the treatment of hemodynamically significant patent ductus arteriosus (hsPDA) in preterm infants. This is a multicenter randomized controlled study. Infants with a gestational age of 25
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.