Evidence map›Paper›PMID 32888084›Full record

ArticlePharmaceutical research2020

Lauroylated Histidine-Enriched S4

Catarina M Morais, Ana M Cardoso, Luísa Aguiar, Nuno Vale, Clévio Nóbrega, Mónica Zuzarte, Paula Gomes, Maria C Pedroso de Lima, Amália S Jurado

Abstract read
PubMed Publisher
In one paragraph

Article in Pharmaceutical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Catarina M MoraisUniversity of Coimbra, CNC-Center for Neuroscience and Cell Biology, Department of Life Sciences, Calçada Martim de Freitas, 3000-456, Coimbra, Portugal.
Ana M CardosoCNC- Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal.
Luísa AguiarLAQV-REQUIMTE, Department of Chemistry and Biochemistry Faculty of Sciences, University of Porto, Porto, Portugal.
Nuno ValeIPATIMUP, Laboratory of Pharmacology, Department of Drug Sciences Faculty of Pharmacy, University of Porto, Porto, Portugal.
Clévio NóbregaCNC- Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal.
Mónica ZuzarteCoimbra Institute for Clinical and Biomedical Research (iCBR) Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Paula GomesLAQV-REQUIMTE, Department of Chemistry and Biochemistry Faculty of Sciences, University of Porto, Porto, Portugal.
Maria C Pedroso de LimaCNC- Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal.
Amália S JuradoUniversity of Coimbra, CNC-Center for Neuroscience and Cell Biology, Department of Life Sciences, Calçada Martim de Freitas, 3000-456, Coimbra, Portugal. asjurado@bioq.uc.pt.ORCID http://orcid.org/0000-0001-7095-5337
Universidade do Porto · PTUniversity of Coimbra · PTCentro de Neurociências e Biologia Celular · PTAlgarve Biomedical Center · PT

Funding

European Regional Development Fund project CENTRO-01-0145-FEDER-000008: BrainHealth 2020Fundação para a Ciência e a Tecnologia IF/00092/2014Fundação para a Ciência e a Tecnologia PD/BD/106035/2015Fundação para a Ciência e a Tecnologia projects POCI-01-0145-FEDER-016390: CANCEL STEM and POCI-01-0145-FEDER-007440; UIDB/04539/2020Fundação para a Ciência e a Tecnologia SFRH/BD/79077/2011Fundação para a Ciência e a Tecnologia UID/MULTI/04378/2013Fundação para a Ciência e a Tecnologia UID/QUI/50006/2013
6 · The paper itself

Abstract

purposeThis study aimed to endow the cell-penetrating peptide (CPP) S4

methodsPeptide/siRNA complexes were prepared with two new derivatives of the CPP S4

resultsPeptide/siRNA complexes prepared with the C12-H

conclusionsThese encouraging results pave the way for a potential application of the C12-H

Indexed as

Gene SilencingCell Line, TumorCell-Penetrating PeptidesCell SurvivalDown-RegulationDrug Delivery SystemsGenetic TherapyHistidineHumansLauric AcidsNeoplasmsPeptidesRNA, Small InterferingStearoyl-CoA DesaturaseCell-Penetrating PeptidesHistidinelauric acidLauric AcidsPeptidesRNA, Small InterferingS4(13)-PV peptideStearoyl-CoA Desaturasecancercell-penetrating peptidecell viabilitygene silencingstearoyl-CoA desaturase-1

Identifiers

PMID32888084
OpenAlexW3083631963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.