Evidence map›Paper›PMID 32888047›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2021

Functional electrical stimulation (FES)-assisted rowing combined with zoledronic acid, but not alone, preserves distal femur strength and stiffness in people with chronic spinal cord injury.

Y Fang, L R Morse, N Nguyen, R A Battaglino, R F Goldstein, K L Troy

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
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  4. Review
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  6. Article
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  8. Review
  9. Effect of External Mechanical Stimuli on Human Bone: a narrative review.Progress in biomedical engineering (Bristol, England) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Y FangDepartment of Mechanical Engineering, Northern Arizona University, Flagstaff, AZ, USA.
L R MorseDepartment of Rehabilitation Medicine, University of Minnesota, Minneapolis, MN, USA.
N NguyenDepartment of Rehabilitation Medicine, University of Minnesota, Minneapolis, MN, USA.
R A BattaglinoDepartment of Rehabilitation Medicine, University of Minnesota, Minneapolis, MN, USA.
R F GoldsteinSpaulding Rehabilitation Hospital, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Cambridge, MA, USA.
K L TroyDepartment of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA. ktroy@wpi.edu.ORCID https://orcid.org/0000-0002-8135-0066
University of Minnesota · USHarvard University · USNorthern Arizona University · USWorcester Polytechnic Institute · US

Funding

U.S. Department of Defense W81XWH-10-1-1043
6 · The paper itself

Abstract

We investigated the effect of 12 months of functional electrical stimulation-assisted rowing with and without zoledronic acid (ZA) on computationally estimated bone strength and stiffness in individuals with spinal cord injury. We found that rowing with ZA, but not rowing alone, improved stiffness at the distal femur, but not the proximal tibia.

introductionPeople with spinal cord injury (SCI) have high fracture risk at the knee after the injury. Therapies that prevent bone loss or stimulate an anabolic response in bone have been proposed to reduce fractures. Zoledronic acid (ZA) is a potent bisphosphonate that inhibits osteoclastic resorption. Functional electrical stimulation (FES)-assisted rowing is a potentially osteogenic exercise involving mechanical stimulation to the lower extremities. Here, we investigated the effect of FES-assisted rowing with and without ZA on bone strength and stiffness in individuals with SCI.

methodsTwenty individuals from a cohort of adults with SCI who participated in a clinical trial were included in the study. CT scans of their knees before and after the intervention were converted to finite element models. Bone failure strength (T

resultsT

conclusionOverall, we observed increases in bone strength at the distal femur but not the proximal tibia, with FES-assisted rowing combined with ZA treatment. Rowing alone did not significantly prevent bone loss at either site, which might be attributed to insufficient mechanical loading.

Indexed as

Spinal Cord InjuriesWater SportsAdultBone DensityElectric StimulationFemurHumansZoledronic AcidZoledronic AcidFEFinite element modelingQCTQuantitative computed tomography

Identifiers

PMID32888047
OpenAlexW3083220466

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.