ArticleScientific reports2020
Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos.
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Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
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Who cites it
30 citing papers in PubMed, 55 citations in OpenAlex.
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- Optimizing CRISPR precision in mouse embryos via microhomology-mediated end joining-dominant targeting.Communications biology · 2026Article
- Diverse species of animal models in epilepsy research: Progress and perspectives.Zoological research · 2025Review
- Morpholino Knockdown in Zebrafish: A Tool to Investigate the Functional Impact of Variants of Unknown Significance in Mitochondrial Diseases.Neuromolecular medicine · 2025Review
- Disrupted endosomal trafficking of the Vangl-Celsr polarity complex underlies congenital anomalies in Xenopus trachea-esophageal morphogenesis.Developmental cell · 2025Article
- Comparative analysis of multiple DNA double-strand break repair pathways in CRISPR-mediated endogenous tagging.Communications biology · 2025Article
- X-CRISP: Domain-Adaptable and Interpretable CRISPR Repair Outcome Prediction.bioRxiv : the preprint server for biology · 2025Article
- Optimizing gRNA selection for high-penetrance F0 CRISPR screening for interrogating disease gene function.Nucleic acids research · 2025Article
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- X-CRISP: domain-adaptable and interpretable CRISPR repair outcome prediction.Bioinformatics advances · 2025Article
- Characterisation and automated quantification of induced seizure-related behaviours in Xenopus laevis tadpoles.Journal of neurochemistry · 2024Article
- Dual activities of an X-family DNA polymerase regulate CRISPR-induced insertional mutagenesis across species.Nature communications · 2024Article
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- Modelling human genetic disorders in Xenopus tropicalis.Disease models & mechanisms · 2024Review
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- Myelination generates aberrant ultrastructure that is resolved by microglia.The Journal of cell biology · 2023Article
- Deep learning in CRISPR-Cas systems: a review of recent studies.Frontiers in bioengineering and biotechnology · 2023Review
- CRISPR/Cas9 Gene Disruption Studies in FMethods in molecular biology (Clifton, N.J.) · 2023Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Thomas Naert *Department of Biomedical Molecular Biology, Ghent University, Technologiepark 71, 9052, Ghent (Zwijnaarde), Belgium.
Dieter Tulkens *Department of Biomedical Molecular Biology, Ghent University, Technologiepark 71, 9052, Ghent (Zwijnaarde), Belgium.
Nicole A EdwardsDivision of Developmental Biology, Perinatal Institute, and Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children's Hospital, Cincinnati, USA.
Marjolein CarronDepartment of Biomedical Molecular Biology, Ghent University, Technologiepark 71, 9052, Ghent (Zwijnaarde), Belgium.
Nikko-Ideen ShaidaniNational Xenopus Resource and Eugene Bell Center for Regenerative Biology and Tissue Engineering, Marine Biological Laboratory, Woods Hole, MA, 02543, USA.
Marcin WlizlaNational Xenopus Resource and Eugene Bell Center for Regenerative Biology and Tissue Engineering, Marine Biological Laboratory, Woods Hole, MA, 02543, USA.
Annekatrien BoelCenter for Medical Genetics, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
Suzan DemuynckDepartment of Biomedical Molecular Biology, Ghent University, Technologiepark 71, 9052, Ghent (Zwijnaarde), Belgium.
Marko E HorbNational Xenopus Resource and Eugene Bell Center for Regenerative Biology and Tissue Engineering, Marine Biological Laboratory, Woods Hole, MA, 02543, USA.
Paul CouckeCenter for Medical Genetics, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
Andy WillaertCenter for Medical Genetics, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
Aaron M ZornDivision of Developmental Biology, Perinatal Institute, and Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children's Hospital, Cincinnati, USA.
Kris VleminckxDepartment of Biomedical Molecular Biology, Ghent University, Technologiepark 71, 9052, Ghent (Zwijnaarde), Belgium. kris.vleminckx@irc.UGent.be.
Ghent University Hospital · BEMarine Biological Laboratory · USCincinnati Children's Hospital Medical Center · USGhent University · BECancer Research Institute Ghent · BE
Funding
Project-3: Modeling EA/TEF in human organoidsP01HD093363 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI Wendy K Chung, Paul scot Kingma · 2017 to 2026
$16.2MResource CoreP40OD010997 · OD · MARINE BIOLOGICAL LABORATORY · PI Marko E Horb · 2012 to 2026
$13.1MXenopus Mutant ResourceR24OD030008 · OD · MARINE BIOLOGICAL LABORATORY · PI Marko E Horb · 2020 to 2026
$6.0MXenopus models of human disease by targeted genome editingR01HD084409 · NICHD · MARINE BIOLOGICAL LABORATORY · PI HORB, MARKO E · 2015 to 2019
$2.9MEnhancing CRISPR-Cas for disease modeling in XenopusR21OD023810 · OD · MARINE BIOLOGICAL LABORATORY · PI HORB, MARKO E · 2019 to 2020
$415kNICHD NIH HHS P01 HD093363NICHD NIH HHS R01 HD084409NIH HHS P40 OD010997NIH HHS R21 OD023810NIH HHS R24 OD030008
Abstract
CRISPR/Cas9 genome editing has revolutionized functional genomics in vertebrates. However, CRISPR/Cas9 edited F
Indexed as
CRISPR-Cas SystemsPenetranceAnimalsClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Associated Protein 9Frameshift MutationGene EditingGene FrequencyHEK293 CellsHumansMiceMouse Embryonic Stem CellsRNA, Guide, CRISPR-Cas SystemsXenopus laevisZebrafishCRISPR-Associated Protein 9RNA, Guide, CRISPR-Cas Systems
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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.