ArticleScientific reports2020
The value of intra-operative electrographic biomarkers for tailoring during epilepsy surgery: from group-level to patient-level analysis.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Inroads into epilepsy through high-frequency oscillations: Achievements and benchmark areas for improvement.Epilepsia · 2026Review
- Thermosensitive/thermochromic silicone and infrared thermography mapping in 60 consecutive cases of epilepsy surgery.Surgical neurology international · 2024Article
- Phase-Amplitude Coupling Localizes Pathologic Brain with Aid of Behavioral Staging in Sleep.Life (Basel, Switzerland) · 2023Article
- Article
- Interictal Connectivity Revealed by Granger Analysis of Stereoelectroencephalography: Association With Ictal Onset Zone, Resection, and Outcome.Neurosurgery · 2022Article
- Deep learning for epileptogenic zone delineation from the invasive EEG: challenges and lookouts.Brain communications · 2022Article
- An electronic neuromorphic system for real-time detection of high frequency oscillations (HFO) in intracranial EEG.Nature communications · 2021Article
- A spiking neural network (SNN) for detecting high frequency oscillations (HFOs) in the intraoperative ECoG.Scientific reports · 2021Article
- Automatic Detection of High-Frequency Oscillations Based on an End-to-End Bi-Branch Neural Network and Clinical Cross-Validation.Computational intelligence and neuroscience · 2021Article
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9 authors.
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Abstract
Signal analysis biomarkers, in an intra-operative setting, may be complementary tools to guide and tailor the resection in drug-resistant focal epilepsy patients. Effective assessment of biomarker performances are needed to evaluate their clinical usefulness and translation. We defined a realistic ground-truth scenario and compared the effectiveness of different biomarkers alone and combined to localize epileptogenic tissue during surgery. We investigated the performances of univariate, bivariate and multivariate signal biomarkers applied to 1 min inter-ictal intra-operative electrocorticography to discriminate between epileptogenic and non-epileptogenic locations in 47 drug-resistant people with epilepsy (temporal and extra-temporal) who had been seizure-free one year after the operation. The best result using a single biomarker was obtained using the phase-amplitude coupling measure for which the epileptogenic tissue was localized in 17 out of 47 patients. Combining the whole set of biomarkers provided an improvement of the performances: 27 out of 47 patients. Repeating the analysis only on the temporal-lobe resections we detected the epileptogenic tissue in 29 out of 30 combining all the biomarkers. We suggest that the assessment of biomarker performances on a ground-truth scenario is required to have a proper estimate on how biomarkers translate into clinical use. Phase-amplitude coupling seems the best performing single biomarker and combining biomarkers improves localization of epileptogenic tissue. Performance achieved is not adequate as a tool in the operation theater yet, but it can improve the understanding of pathophysiological process.
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