ArticleNature communications2020
Chromosome 1q21.2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarction.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 2 pooled it
8.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation.Nature genetics · 2023Pooled it
- Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases.Nature communications · 2021Pooled it
- A Genome-Wide Association Study of Takotsubo Syndrome.JACC. Basic to translational science · 2026Article
- Spontaneous Coronary Artery Dissection and Takotsubo Syndrome: Converging Mechanisms, Diagnostic Pitfalls, and a Unified Clinical Algorithm.Journal of clinical medicine · 2026Review
- ADAM and ADAMTS proteases as integrative hubs in heart failure pathogenesis and therapy.iScience · 2026Review
- Prevalence, Predictors, and Clinical Outcomes of Cervical Arterial Dissection in Patients with Spontaneous Coronary Artery Dissection: A Multicenter Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Evaluating Individual Level Performance of Polygenic Risk Scores Using Early Onset High Genetic Risk Coronary Artery Disease as a Benchmark.medRxiv : the preprint server for health sciences · 2026Article
- The Role of Serum Biomarkers for the Differential Diagnosis and Prognostic Assessment of Myocardial Infarction with Non-Obstructive Coronary Arteries: A Narrative Review.Journal of clinical medicine · 2026Review
- Spontaneous coronary artery dissection as a threshold disorder of coronary wall integrity.Frontiers in cardiovascular medicine · 2026Review
- Senescence-related epicardial adipocyte genes lead to immune infiltration and myocardial infarction progression.Frontiers in cardiovascular medicine · 2026Article
- Statistical construction of calibrated prediction intervals for polygenic score-based phenotype prediction.Nature genetics · 2025Article
- Spontaneous Coronary Artery Dissection (SCAD): Unveiling the Enigma of the Unexpected Coronary Event.Current atherosclerosis reports · 2025Review
- Migraine and spontaneous coronary artery dissection: A retrospective case-control study.Headache · 2025Article
- Cross-Ancestry Associations of Spontaneous Coronary Artery Dissection Genetic Risk With Coronary Atherosclerosis and Migraine Headache.Journal of the American Heart Association · 2025Article
- Spontaneous Coronary Artery Dissection and a Family History of Aortic Dissection: A Genetic Association Study.Journal of the American Heart Association · 2025Article
- Spontaneous Coronary Artery Dissection: A Narrative Review of Epidemiology and Public Health Implications.Medicina (Kaunas, Lithuania) · 2025Review
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Beyond the Norm: Decoding Spontaneous Coronary Artery Dissection as an Unusual Cause of Acute Coronary Syndrome.HCA healthcare journal of medicine · 2025Review
- Spontaneous Coronary Artery Dissection: Current Knowledge, Research Gaps, and Innovative Research Initiatives:JACC. Advances · 2024Review
- Transcriptome analysis of the aortic coarctation area.Journal of molecular and cellular cardiology plus · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 8 institutions in 2 countries.
Jacqueline Saw *Vancouver General Hospital, Division of Cardiology, University of British Columbia, Vancouver, BC, Canada. jsaw@mail.ubc.ca.ORCID http://orcid.org/0000-0002-7027-984X
Min-Lee Yang *Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Mark TrinderVancouver General Hospital, Division of Cardiology, University of British Columbia, Vancouver, BC, Canada.
Catherine TcheandjieuVA Palo Alto Health Care System, Palo Alto, CA, USA.
Chang XuDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Andrew StarovoytovVancouver General Hospital, Division of Cardiology, University of British Columbia, Vancouver, BC, Canada.
Isabelle BirtDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-9909-1154
Michael R MathisDepartment of Anesthesiology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-9697-2212
Kristina L HunkerDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Ellen M SchmidtDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-1198-7536
Linda JacksonCentre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Natalia Fendrikova-MahlayHeart and Vascular Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Matthew ZawistowskiDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3005-083X
Chad M BrummettDepartment of Anesthesiology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Sebastian ZoellnerDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Alexander KatzDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-9706-9490
Dawn M ColemanVascular Surgery Section, Department of Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Kirby SwanDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3501-204X
Christopher J O'DonnellVA Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2667-8624
Million Veteran Program
Xiang ZhouDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-4331-7599
Jun Z LiDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-6727-0812
Heather L GornikHeart and Vascular Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Themistocles L AssimesVA Palo Alto Health Care System, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0003-2349-0009
James C StanleyVascular Surgery Section, Department of Surgery, Michigan Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Liam R BrunhamVancouver General Hospital, Division of Cardiology, University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0002-3686-3807
Santhi K GaneshDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. sganesh@umich.edu.
University of Michigan · USUniversity of British Columbia · CACleveland Clinic · USMichigan Medicine · USVA Palo Alto Health Care System · USNational Institutes of Health · USUniversity of British Columbia Hospital · CAVA Boston Healthcare System · US
Funding
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7MClinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5MStructural Determinants Of Ceruloplasmin Inflammatory ActivityP01HL076491 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L · 2004 to 2019
$27.3MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MProject 3: Microbiota generated aryl sulfates and secondary bile acids in cardiometabolic diseaseP01HL147823 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI MICHAEL ANDREW FISCHBACH · 2019 to 2026
$17.0MGut Flora Metabolism of Dietary Phosphatidylcholine and CVDR01HL103866 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L · 2010 to 2023
$10.8MGenetic Studies of The Impact of Hematologic Traits On Cardiovascular DiseaseR01HL122684 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GANESH, SANTHI K · 2015 to 2019
$3.4MHDL Structure, Function and DysfunctionR01HL128300 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L · 2016 to 2019
$3.1MStatistical Methods for Modeling Polygenic Architecture in Association and Re-sequencing StudiesR01HG009124 · NHGRI · YALE UNIVERSITY · PI Xiang Zhou · 2017 to 2026
$3.0MGenetic and Genomic Analysis of Arterial DysplasiaR01HL139672 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GANESH, SANTHI K · 2018 to 2021
$2.9MGenetics of Cardiometabolic Diseases in the VA PopulationI01BX003362 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI Kyong-Mi Chang, Philip S Tsao · 2017 to 2026
–Cardiovascular Disease Risk Factors, Cardiovascular Disease Risk Prediction, and Genetics in the Million Veteran ProgramI01BX004821 · VA · VETERANS HEALTH ADMINISTRATION · PI PETER WYMAN WILSON · 2020 to 2026
–BLRD VA I01 BX003362BLRD VA I01 BX004821CIHR 136799NCATS NIH HHS UL1 TR002548NCRR NIH HHS UL1 RR024989NHGRI NIH HHS R01 HG009124NHLBI NIH HHS P01 HL076491NHLBI NIH HHS P01 HL147823NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL103866NHLBI NIH HHS R01 HL122684NHLBI NIH HHS R01 HL128300NHLBI NIH HHS R01 HL139672
Abstract
Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic cause of myocardial infarction (MI), typically in young women. We undertook a genome-wide association study of SCAD (N
Indexed as
Genes, NeoplasmADAMTS ProteinsCarotid Artery DiseasesChromosomesCohort StudiesCoronary Artery DiseaseCoronary Vessel AnomaliesFemaleFibromuscular DysplasiaGenome-Wide Association StudyHumansLow Density Lipoprotein Receptor-Related Protein-1MaleMeta-Analysis as TopicMicrofilament ProteinsMyocardial InfarctionADAMTSL4 protein, humanADAMTS ProteinsLow Density Lipoprotein Receptor-Related Protein-1LRP1 protein, humanMicrofilament ProteinsPHACTR1 protein, human
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