Evidence map›Paper›PMID 32887758›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2021

The Synthesis and Structural Requirements for Measuring Glucocorticoid Receptor Expression In Vivo with (±)-

Yangjie Huang, Ning Zhao, Yung-Hua Wang, Charles Truillet, Junnian Wei, Matthew F L Parker, Joseph E Blecha, Christopher R Drake, Henry F VanBrocklin, Diego Garrido-Ruiz and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Yangjie HuangDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Ning ZhaoDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Yung-Hua WangDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Charles TruilletImagerie Moleculaire in Vivo, INSERM, CEA, Université Paris Sud, CNRS, Universite Paris Saclay, CEA-Service Hospitalier Frederic Joliot, Orsay, France.
Junnian WeiDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Matthew F L ParkerDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Joseph E BlechaDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Christopher R DrakeSofie Biosciences, Culver City, California.
Henry F VanBrocklinDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Diego Garrido-RuizDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California; and.
Matthew P JacobsonDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California; and.
Rahul AggarwalHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California.
Spencer C BehrDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Robert R FlavellDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
David M WilsonDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Youngho SeoDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Michael J EvansDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California michael.evans@ucsf.edu.
University of California System · USUniversity of California, San Francisco · USUCSF Helen Diller Family Comprehensive Cancer Center · USSofie Biosciences (United States) · USUniversité Paris-Sud · FR

Funding

Development and translation of a novel radioligand to measure pathological changes in glucocorticoid receptor expression in the brainR01MH115043 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EVANS, MICHAEL JOHN · 2018 to 2020
$2.0M
NIMH NIH HHS R01 MH115043
6 · The paper itself

Abstract

Noninvasive methods to study glucocorticoid receptor (GR) signaling are urgently needed to elaborate the complexity of GR signaling in normal physiology and human disorders, as well as to identify selective GR modulators to treat diseases. Here, we report evidence supporting translational studies with (±)-

Indexed as

Carbon RadioisotopesGene Expression RegulationPositron-Emission TomographyAnimalsChemistry Techniques, SyntheticMiceProtein DomainsReceptors, GlucocorticoidTissue DistributionCarbon-11Carbon RadioisotopesReceptors, Glucocorticoidcarbon‐11dosimetry studyglucocorticoid receptor (GR)molecular imagingPET

Identifiers

PMID32887758
PMCPMC8844266
OpenAlexW3083065418

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.